Association between sputum smear status and local immune responses at the site of disease in HIV-infected patients with pulmonary tuberculosis

Mwandumba, Henry ORCID: https://orcid.org/0000-0003-4470-3608, Squire, Bertie ORCID: https://orcid.org/0000-0001-7173-9038, White, S. A., Nyirenda, M. H., Kampondeni, S. D., Rhoades, E. R., Zijistra, E. E., Molyneux, Malcolm E and Russell, D. G. (2008) 'Association between sputum smear status and local immune responses at the site of disease in HIV-infected patients with pulmonary tuberculosis'. Tuberculosis, Vol 88, Issue 1, pp. 58-63.

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Abstract

Infection with human immunodeficiency virus (HIV) may affect the clinical presentation of pulmonary tuberculosis (TB). To investigate the association between sputum smear status at presentation and local pulmonary immune responses in HIV-infected patients with pulmonary TB, we compared the cellular and cytokine profiles in bronchoalveolar lavage (BAL) fluid obtained from the site of lung disease in 22 sputum smear- and culture-positive, and 17 sputum smear-negative but culture-positive pulmonary TB patients. Smear-positive patients had significantly higher BAL fluid concentrations of IL-6 (p = 0.007), IL-8 (p = 0.02), IL-10 (p = 0.03) and IFN-gamma (p = 0.008) than smear-negative patients. No significant differences in the proportions of examined BAL cells were found. We concluded that sputum smear-positive TB was associated with greater pro-inflammatory and immunomodulatory cytokine responses at the site of lung disease than sputum smear-negative disease. The local immune responses may affect the clinical presentation of active pulmonary TB in HIV-infected patients. (c) 2007 Elsevier Ltd. All rights reserved.

Item Type:	Article
Uncontrolled Keywords:	bronchoalveolar lavage cellular response cytokine response hiv pulmonary tb sputum smear status immunodeficiency-virus-infection alveolar macrophages interferon-gamma mycobacterium-tuberculosis activation correlate
Subjects:	WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General) WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections QY Clinical Pathology > Diagnostic Tests > QY 120 Sputum WF Respiratory System > Tuberculosis > WF 220 Diagnosis. Prognosis WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.5 Complications QY Clinical Pathology > QY 4 General works WB Practice of Medicine > Diagnosis > General Diagnosis > WB 200 Physical diagnosis (General) WF Respiratory System > Tuberculosis > WF 300 Pulmonary tuberculosis
Faculty: Department:	Groups (2002 - 2012) > Clinical Group
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.tube.2007.06.003
Depositing User:	Helen Rigby
Date Deposited:	16 Mar 2010 14:27
Last Modified:	17 Aug 2022 08:56
URI:	https://archive.lstmed.ac.uk/id/eprint/876

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