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CD4 count recovery following initiation of HIV antiretroviral therapy in older childhood and adolescence.

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Simms, Victoria, Rylance, Sarah, Bandason, Tsitsi, Dauya, Ethel, Mchugh, Grace, Munyati, Shungu, Mujuru, Hilda, Rowland-Jones, Sarah L, Weiss, Helen A and Ferrand, Rashida A (2018) 'CD4 count recovery following initiation of HIV antiretroviral therapy in older childhood and adolescence.'. AIDS, Vol 32, Issue 14, pp. 1977-1982.

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Abstract

OBJECTIVE
To investigate CD4 cell count recovery following ART initiation in perinatally HIV-infected children diagnosed in later childhood.

DESIGN
Observational prospective cohort study of newly diagnosed children aged 6-15 in Harare, Zimbabwe.

METHODS
Participants were enrolled into a cohort at seven primary healthcare clinics between January 2013 and January 2015. ART was initiated according to national guidelines and CD4 counts were performed 6-monthly over 18 months. The relationship between CD4 count and time on ART was investigated using regression analysis with fixed (population) and random (individual) effects, and age at ART initiation as a covariate.

RESULTS
Of the 307 participants who initiated ART, the median age at initiation was 11.7 years (interquartile range 9.6-13.8). The addition of an individual intercept and slope as random effects significantly improved the model fit compared to a fixed effects-only model. CD4 response (using a square root transformation) was best modelled using a 2-knot linear spline, with significant effects of time on ART and age at ART initiation. Younger children had a higher CD4 count at ART initiation (-17.9 cells/mm per year of age), an accelerated increase during the first three months on ART (-38.9 cells/mm per year of age at day 84), and a sustained higher CD4 count.

CONCLUSIONS
Earlier ART initiation in older children is associated with accelerated CD4 count recovery and lasting immune reconstitution. Our findings support WHO guidance recommending ART initiation in all children, irrespective of disease stage and CD4 count.

Item Type: Article
Subjects: QU Biochemistry > Proteins. Amino Acids. Peptides > QU 55 Proteins
WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections
WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.2 Therapy
WS Pediatrics > By Age Groups > WS 460 Adolescence (General)
Faculty: Department: Clinical Sciences & International Health > International Public Health Department
Digital Object Identifer (DOI): https://doi.org/10.1097/QAD.0000000000001905
Depositing User: Stacy Murtagh
Date Deposited: 26 Jun 2018 16:57
Last Modified: 06 Dec 2019 16:10
URI: https://archive.lstmed.ac.uk/id/eprint/8851

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