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A Serological Survey of Human Onchocerciasis in Yemen.

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Mackenzie, Charles, Al-Kubati, Abdul-Samid, Al-Qubati, Yasin, Behan-Braman, Ashley, Kubofcik, Joseph, Hopkins, Adrian and Nutman, Thomas B (2018) 'A Serological Survey of Human Onchocerciasis in Yemen.'. American Journal of Tropical Medicine and Hygiene, Vol 99, Issue 4, pp. 1049-1052.

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Abstract

Yemen is a country that has been treating severe cases of oncho-dermatitis since 1992 and is now moving to a program aimed at the elimination of the transmission of . It is important to ensure that the currently acceptable tools used in epidemiological assessment of onchocerciasis in Africa and Latin America also apply to Yemen. Five hundred and ten blood samples from three known -endemic areas, locations that have never been under a mass treatment program, were tested for the presence of antibodies against a panel of -specific antigens using enzyme-linked immunosorbent assay (Ov16) and luciferase immunoprecipitation system (OvFAR-1 and Ov-MSA1) assays. Overall, 31.4% of the samples tested were positive, with positivity increasing with age. Positivity was seen in 76.5% of those presenting with clinical onchocerciasis but importantly also in more than 28.5% of those defined as free of oncho-dermatitis; these latter individuals are likely to be serving as a source for persistent reinfection. This study supports the use of the current -specific serologic methodology in Yemen.

Item Type: Article
Subjects: QW Microbiology and Immunology > Antigens and Antibodies. Toxins and Antitoxins > QW 570 Serology.
WA Public Health > WA 30 Socioeconomic factors in public health (General)
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 885 Onchocerciasis
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.4269/ajtmh.18-0051
Depositing User: Stacy Murtagh
Date Deposited: 14 Aug 2018 14:52
Last Modified: 06 Aug 2019 01:02
URI: https://archive.lstmed.ac.uk/id/eprint/9064

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