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Efficacy and safety of a single-dose veterinary preparation of ivermectin versus 7-day high-dose albendazole for chronic strongyloidiasis

Suputtamongkol, Y., Kungpanichkul, N., Silpasakorn, S. and Beeching, Nicholas ORCID: https://orcid.org/0000-0002-7019-8791 (2008) 'Efficacy and safety of a single-dose veterinary preparation of ivermectin versus 7-day high-dose albendazole for chronic strongyloidiasis'. International Journal of Antimicrobial Agents, Vol 31, Issue 1, pp. 46-49.

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Abstract

A prospective. randomised, open study compared a 7-day course of oral albendazole 800 mg daily with a single oral dose of the parenteral veterinary preparation of ivermectin in 42 Thai patients with chronic strongyloidiasis (21 in each group). The primary endpoints were relief of symptoms (if present) and clearance of Strongy1oides larvae from faeces immediately after treatment and at follow-up to 16 weeks later. Cure rates in the albendazole and ivermectin groups were 38.1% and 76.2%, respectively, (P = 0.029) in the intention-to-treat analysis and 50% and 88.9%, respectively, (P=0.023) in the per-protocol analysis. Acute generalised exanthernatous pustulosis developed in one patient who was treated with the veterinary preparation of ivermectin. This study confirms the superiority of ivermectin compared with albendazole as well as that oral use of the parenteral veterinary preparation in humans is as effective and safe as human preparations. (C) 2007 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

Item Type: Article
Uncontrolled Keywords: ivermectin strongyloidiasis albendazole veterinary drugs thailand stercoralis
Subjects: WB Practice of Medicine > Medical Climatology > WB 710 Diseases of geographic areas
QV Pharmacology > Drug Standardization. Pharmacognosy. Medicinal Plants > QV 771 Standardization and evaluation of drugs
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 865 Strongyloidiasis
QV Pharmacology > QV 34 Experimental pharmacology (General)
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 850 Nematode infections (General)
QV Pharmacology > QV 38 Drug action.
Faculty: Department: Groups (2002 - 2012) > Clinical Group
Digital Object Identifer (DOI): https://doi.org/10.1016/j.ijantimicag.2007.08.014
Depositing User: Users 43 not found.
Date Deposited: 04 Aug 2010 11:43
Last Modified: 06 Feb 2018 13:00
URI: http://archive.lstmed.ac.uk/id/eprint/929

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