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Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: trends in pyrethroid resistance during a WHO-coordinated multicountry prospective study

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Cook, Jackie, Tomlinson, Sean, Kleinschmidt, Immo, Donnelly, Martin ORCID: https://orcid.org/0000-0001-5218-1497, Akogbeto, Martin, Adechoubou, Alioun, Massougbodji, Achile, Oke-Sopoh, Mariam, Corbel, Vincent, Cornelie, Sylvie, Hounto, Aurore, Etang, Josiane, Awono-Ambene, Herman Parfait, Bigoga, Jude, Elysee Mandeng, Stanislas, Njeambosay, Boris, Tabue, Raymond and Kouambeng, Celestin (2018) 'Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: trends in pyrethroid resistance during a WHO-coordinated multicountry prospective study'. Parasites and Vectors, Vol 11, Issue 550.

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Abstract

Background: Increasing pyrethroid resistance has been an undesirable correlate of the rapid increase in coverage of insecticide-treated nets (ITNs) since 2000. Whilst monitoring of resistance levels has increased markedly over this period, longitudinal monitoring is still lacking, meaning the temporal and spatial dynamics of phenotypic resistance in the context of increasing ITN coverage are unclear.
Methods: As part of a large WHO-co-ordinated epidemiological study investigating the impact of resistance on malaria infection, longitudinal monitoring of phenotypic resistance to pyrethroids was undertaken in 290 clusters across Benin, Cameroon, India, Kenya and Sudan.
Mortality in response to pyrethroids in the major anopheline vectors in each location was recorded during consecutive years using standard WHO test procedures. Trends in mosquito mortality were examined using generalised linear mixed-effect models.
Results: Insecticide resistance (using the WHO definition of mortality < 90%) was detected in clusters in all countries across the study period. The highest mosquito mortality (lowest resistance frequency) was consistently reported from India, in an area where ITNs had only
recently been introduced. Substantial temporal and spatial variation was evident in mortality measures in all countries. Overall, a trend of decreasing mosquito mortality (increasing resistance frequency) was recorded (Odds Ratio per year: 0.79 per year (95% CI: 0.79–0.81,
P < 0.001). There was also evidence that higher net usage was associated with lower mosquito mortality in some countries.
Discussion: Pyrethroid resistance increased over the study duration in four out of five countries. Insecticide-based vector control may be compromised as a result of ever higher resistance frequencies.

Item Type: Article
Subjects: QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes
QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control
WA Public Health > Preventive Medicine > WA 240 Disinfection. Disinfestation. Pesticides (including diseases caused by)
Faculty: Department: Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI): https://doi.org/10.1186/s13071-018-3101-4
Depositing User: Stacy Murtagh
Date Deposited: 01 Nov 2018 13:15
Last Modified: 01 Nov 2018 13:15
URI: http://archive.lstmed.ac.uk/id/eprint/9380

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