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Systematic review of indoor residual spray efficacy and effectiveness against Plasmodium falciparum in Africa.

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Sherrard-Smith, Ellie, Griffin, Jamie T, Winskill, Peter, Corbel, Vincent, Pennetier, Cédric, Djénontin, Armel, Moore, Sarah, Richardson, Jason, Müller, Pie, Edi, Constant, Protopopoff, Natacha, Oxborough, Richard, Agossa, Fiacre, N'Guessan, Raphael, Rowland, Mark and Churcher, Thomas S (2018) 'Systematic review of indoor residual spray efficacy and effectiveness against Plasmodium falciparum in Africa.'. Nature Communications, Vol 9, Issue 1, p. 4982.

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Abstract

Indoor residual spraying (IRS) is an important part of malaria control. There is a growing list of insecticide classes; pyrethroids remain the principal insecticide used in bednets but recently, novel non-pyrethroid IRS products, with contrasting impacts, have been introduced. There is an urgent need to better assess product efficacy to help decision makers choose effective and relevant tools for mosquito control. Here we use experimental hut trial data to characterise the entomological efficacy of widely-used, novel IRS insecticides. We quantify their impact against pyrethroid-resistant mosquitoes and use a Plasmodium falciparum transmission model to predict the public health impact of different IRS insecticides. We report that long-lasting IRS formulations substantially reduce malaria, though their benefit over cheaper, shorter-lived formulations depends on local factors including bednet use, seasonality, endemicity and pyrethroid resistance status of local mosquito populations. We provide a framework to help decision makers evaluate IRS product effectiveness.

Item Type: Article
Subjects: QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 256 Antimalarials
QX Parasitology > Protozoa > QX 135 Plasmodia
QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes
QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department: IVCC
Digital Object Identifer (DOI): https://doi.org/10.1038/s41467-018-07357-w
SWORD Depositor: JISC Pubrouter
Depositing User: Stacy Murtagh
Date Deposited: 12 Dec 2018 10:34
Last Modified: 12 Dec 2018 10:34
URI: https://archive.lstmed.ac.uk/id/eprint/9780

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