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Carbapenemases on the move: it's good to be on ICEs.

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Botelho, João, Roberts, Adam, León-Sampedro, Ricardo, Grosso, Filipa and Peixe, Luísa (2018) 'Carbapenemases on the move: it's good to be on ICEs.'. Mobile DNA, Vol 9, p. 37.

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Abstract

Background
The evolution and spread of antibiotic resistance is often mediated by mobile genetic elements. Integrative and conjugative elements (ICEs) are the most abundant conjugative elements among prokaryotes. However, the contribution of ICEs to horizontal gene transfer of antibiotic resistance has been largely unexplored.
Results
Here we report that ICEs belonging to mating-pair formation (MPF) classes G and T are highly prevalent among the opportunistic pathogen , contributing to the spread of carbapenemase-encoding genes (CEGs). Most CEGs of the MPF class were encoded within class I integrons, which co-harbour genes conferring resistance to other antibiotics. The majority of the integrons were located within Tn-like and composite transposons. Conserved attachment site could be predicted for the MPF class ICEs. MPF class ICEs carried the CEGs within composite transposons which were not associated with integrons.
Conclusions
The data presented here provides a global snapshot of the different CEG-harbouring ICEs and sheds light on the underappreciated contribution of these elements to the evolution and dissemination of antibiotic resistance on .

Item Type: Article
Subjects: QV Pharmacology > Anti-Bacterial Agents. Tissue Extracts > QV 350 Anti-bacterial agents (General or not elsewhere classified)
QV Pharmacology > QV 38 Drug action.
QW Microbiology and Immunology > QW 45 Microbial drug resistance. General or not elsewhere classified.
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1186/s13100-018-0141-4
Depositing User: Stacy Murtagh
Date Deposited: 08 Jan 2019 13:21
Last Modified: 17 Jan 2019 10:33
URI: http://archive.lstmed.ac.uk/id/eprint/9943

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