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Two Randomized Trials of Effect of Live Attenuated Influenza Vaccine on Pneumococcal Colonization

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Rylance, Jamie ORCID: https://orcid.org/0000-0002-2323-3611, de Steenhuijsen Piters, Wouter, Mina, Michael, Bogaert, Debby, French, Neil and Ferreira, Daniela ORCID: https://orcid.org/0000-0002-0594-0902 (2019) 'Two Randomized Trials of Effect of Live Attenuated Influenza Vaccine on Pneumococcal Colonization'. American Journal of Respiratory and Critical Care Medicine, Vol 199, Issue 9, pp. 1160-1163.

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Abstract

The human nasopharynx is frequently colonized by Streptococcus pneumoniae (the pneumococcus), serving as the reservoir for transmission, a state which necessarily precedes invasive pneumococcal infection. Influenza infection increases pneumococcal colonization density and dysregulates host immune responses, increasing the risk of secondary bacterial pneumonia and death.

Item Type: Article
Additional Information: Correspondence
Subjects: WA Public Health > Preventive Medicine > WA 115 Immunization
WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 204 Pneumococcal pneumonia. Staphylococcal pneumonia
WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 217 Pneumococcal infections
WC Communicable Diseases > Virus Diseases > Viral Respiratory Tract Infections. Respirovirus Infections > WC 515 Human influenza
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Clinical Sciences & International Health > International Public Health Department
Digital Object Identifer (DOI): https://doi.org/10.1164/rccm.201811-2081LE
Depositing User: Stacy Murtagh
Date Deposited: 14 Feb 2019 16:23
Last Modified: 17 Sep 2019 08:54
URI: https://archive.lstmed.ac.uk/id/eprint/9968

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