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Field, Genetic, and Modeling Approaches Show Strong Positive Selection Acting upon an Insecticide Resistance Mutation in Anopheles gambiae s.s.

Lynd, Amy, Weetman, David ORCID: https://orcid.org/0000-0002-5820-1388, Barbosa, S., Egyir Yawson, A., Mitchell, Sara N., Pinto, J., Hastings, Ian ORCID: https://orcid.org/0000-0002-1332-742X and Donnelly, Martin ORCID: https://orcid.org/0000-0001-5218-1497 (2010) 'Field, Genetic, and Modeling Approaches Show Strong Positive Selection Acting upon an Insecticide Resistance Mutation in Anopheles gambiae s.s.'. Molecular Biology and Evolution, Vol 27, Issue 5, p. 1117.

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Abstract

Alleles subject to strong, recent positive selection will be swept toward fixation together with contiguous sections of the genome. Whether the genomic signatures of such selection will be readily detectable in outbred wild populations is unclear. In this study, we employ haplotype diversity analysis to examine evidence for selective sweeps around knockdown resistance (kdr) mutations associated with resistance to dichlorodiphenyltrichloroethane and pyrethroid insecticides in the mosquito Anopheles gambiae. Both kdr mutations have significantly lower haplotype diversity than the wild-type (nonresistant) allele, with kdr L1014F showing the most pronounced footprint of selection. We complement these data with a time series of collections showing that the L1014F allele has increased in frequency from 0.05 to 0.54 in 5 years,consistent with a maximum likelihood–fitted selection coefficient of 0.16 and a dominance coefficient of 0.25. Our data show that strong, recent positive selective events, such as those caused by insecticide resistance, can be identified in wild insect populations.

Item Type: Article
Uncontrolled Keywords: Anopheles gambiae, malaria, insecticide resistance, selection, knock-down resistance, genome
Subjects: QX Parasitology > Insects. Other Parasites > QX 650 Insect vectors
QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control
QU Biochemistry > Genetics > QU 450 General Works
QX Parasitology > Insects. Other Parasites > QX 515 Anopheles
Faculty: Department: Groups (2002 - 2012) > Vector Group
Digital Object Identifer (DOI): https://doi.org/10.1093/molbev/msq002
Depositing User: Users 183 not found.
Date Deposited: 10 Jun 2010 16:00
Last Modified: 06 Feb 2018 13:00
URI: http://archive.lstmed.ac.uk/id/eprint/998

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