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Reinventing the antimicrobial pipeline in response to the global crisis of antimicrobial-resistant infections

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Singer, Andrew C, Kirchhelle, Claas and Roberts, Adam ORCID: https://orcid.org/0000-0002-0760-3088 (2019) 'Reinventing the antimicrobial pipeline in response to the global crisis of antimicrobial-resistant infections'. F1000Research, Vol 8, Issue 238.

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Official URL: https://f1000research.com/articles/8-238/v1

Abstract

The pipeline for new antibiotics is dry. Despite the creation of public/private initiatives like Combating Antibiotic Resistant Bacteria Biopharmaceutical Accelerator (Carb-X) and the Antimicrobial Resistance (AMR) Centre, the current focus on ‘push-pull’ incentives for the pharmaceutical industry still relies on economic return. We propose a joint, internationally-funded antimicrobial development institute that would fund permanent staff to take on roles previously assigned to pharmaceutical companies. This institute would receive ring-fenced, long-term, core funding from participating countries as well as charities, with the aim to focus on transforming the largely dormant antimicrobial pipeline. Resulting drugs would be sold globally and according to a principle of shared burdens. Our proposed model for antimicrobial development aims to maximise society’s investment, through open science, investment in people, and the sharing of intellectual property.

Item Type:	Article
Subjects:	QS Anatomy > QS 4 General works. Classify here works on regional anatomy QV Pharmacology > QV 38 Drug action. QV Pharmacology > QV 4 General works WB Practice of Medicine > Therapeutics > WB 330 Drug therapy
Faculty: Department:	Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI):	https://doi.org/10.12688/f1000research.18302.1
Depositing User:	Stacy Murtagh
Date Deposited:	11 Mar 2019 11:46
Last Modified:	06 Sep 2019 09:34
URI:	https://archive.lstmed.ac.uk/id/eprint/10342

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