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Brink, A. K., Mahe, C., Watera, C., Lugada, E., Gilks, C.F., Whitworth, J. and French, Neil (2002) 'Diarrhoea, CD4 counts and enteric infections in a community-based cohort of HIV-infected adults in Uganda'. Journal of Infection, Vol 45, Issue 2, pp. 99-106.
Full text not available from this repository.Abstract
Objectives: To examine relationships between diarrhoea, CD4 cell counts and stool pathogens in a community-based cohort of HIV-infected adults in Uganda. Patients and methods: Stool specimens, obtained between October 1995 and December 1997, were linked to patients' symptoms and laboratory results. The relationship between CD4 counts and symptoms was tested using the Wilcoxon rank-sum test and those between organisms and diarrhoea using first a univariate Mantel-Haenszel analysis and then a logistic regression model adjusted for CD4 count and multiple organisms. Results: 1213 HIV-infected individuals (70% women, median CD4 cell count at enrollment 215 cells/mul) were followed for 1224 person years of observation (pyo). 484 stool samples were examined, 35 7 from patients with diarrhoea. The rate of diarrhoea was 661 episodes per 1000 pyo. CD4 counts were significantly lower in individuals with diarrhoea than those without (P < 0.001, Wilcoxon rank-sum test). Forty-nine percent of diarrhoeal stools and 39% of stools from asymptomatic patients contained enteric pathogens. The most frequent isolates were helminths (29.5% of all stools), followed by bacteria (19.2%) and then protozoa (8.9%). Rates of isolation of diarrhoea-associated pathogens were 29%, from diarrhoeal stools and 17% from asymptomatic stools (P = 0.01, χ(2) test). The association between diarrhoea and infection with bacteria or protozoa was weak and there was no association with helminths. Cryptosporidium parvum infection alone was associated with low CD4 counts. Conclusions: Diarrhoea was common and most strongly associated with low CD4 counts. Bacteria were frequently found, even in stools from asymptomatic individuals. Over two-thirds of diarrhoeal episodes were undiagnosed, suggesting that unidentified agents or primary HIV enteropathy are important causes of diarrhoea in this population.
| Item Type: | Article |
|---|---|
| Subjects: | WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries WC Communicable Diseases > Infection. Bacterial Infections > Enteric Infections > WC 260 Enterobacteriaceae and other enteric infections WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections WI Digestive System > WI 407 Diarrhea |
| Digital Object Identifer (DOI): | https://doi.org/10.1053/jinf.2002.1002 |
| Depositing User: | Users 476 not found. |
| Date Deposited: | 19 Dec 2012 14:37 |
| Last Modified: | 21 Nov 2019 15:20 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/2901 |
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