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Pennington, Shaun 
ORCID: https://orcid.org/0000-0002-7160-6275, Ferreira, Daniela ORCID: https://orcid.org/0000-0002-0594-0902, Caamaño-Gutiérrez, E, Reiné, Jesús, Hewitt, C, Hyder-Wright, Angela, Gordon, Stephen ORCID: https://orcid.org/0000-0001-6576-1116 and Gordon, Melita
(2019)
'Nonspecific effects of oral vaccination with live-attenuated Typhi strain Ty21a'. Science Advances, Vol 5, Issue 2, eaau6849.
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Pennington-Sci-Adv-March-19.pdf - Published Version Available under License Creative Commons Attribution. Download (4MB) | Preview |
Abstract
Epidemiological and immunological evidence suggests that some vaccines can reduce all-cause mortality through nonspecific changes made to innate immune cells. Here, we present the first data to describe the nonspecific immunological impact of oral vaccination with live-attenuated Typhi strain Ty21a. We vaccinated healthy adults with Ty21a and assessed aspects of innate and adaptive immunity over the course of 6 months. Changes to monocyte phenotype/function were observed for at least 3 months. Changes to innate and adaptive immune cell cytokine production in response to stimulation with vaccine and unrelated nonvaccine antigens were observed over the 6-month study period. The changes that we have observed could influence susceptibility to infection through altered immune responses mounted to subsequently encountered pathogens. These changes could influence all-cause mortality.
| Item Type: | Article |
|---|---|
| Subjects: | QW Microbiology and Immunology > Bacteria > QW 138 Enterobacteriaceae QW Microbiology and Immunology > Immunotherapy and Hypersensitivity > QW 805 Vaccines. Antitoxins. Toxoids QW Microbiology and Immunology > Immunotherapy and Hypersensitivity > QW 806 Vaccination WA Public Health > Preventive Medicine > WA 110 Prevention and control of communicable diseases. Transmission of infectious diseases |
| Faculty: Department: | Biological Sciences > Department of Tropical Disease Biology Clinical Sciences & International Health > Clinical Sciences Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1126/sciadv.aau6849 |
| Depositing User: | Stacy Murtagh |
| Date Deposited: | 11 Mar 2019 11:36 |
| Last Modified: | 05 Nov 2019 14:57 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/10345 |
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