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Constant Edi, Catherine M. Bjerum, Allassane F. Ouattara, Yashpal S. Chhonker, Louis K. Penali, Aboulaye Méité, Benjamin G. Koudou, Gary J. Weil, Christopher L. King, Daryl J. Murry
Pharmacokinetics, safety, and efficacy of a single co-administered dose of diethylcarbamazine, albendazole and ivermectin in adults with and without Wuchereria bancrofti infection in Côte d’Ivoire
www.plosntds.org
www.plosntds.org
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0 Tc
5.04 0 Td
(<)Tj
/F8 1 Tf
-0.004 Tc
(7)Tj
1.4683 0 Td
(gm/dL.)Tj
3.1238 0 Td
(Biochemical)Tj
5.142 0 Td
(tests)Tj
1.9616 0 Td
(were)Tj
2.1203 0 Td
(performed)Tj
4.473 0 Td
(with)Tj
1.9956 0 Td
(a)Tj
0.652 0 Td
(Piccolo)Tj
3.1521 0 Td
(biochemistry)Tj
-31.6401 -1.2982 Td
(machine)Tj
3.6623 0 Td
(\(Abbott)Tj
3.3619 0 Td
(Labs,)Tj
2.2847 0 Td
(Lake)Tj
2.1146 0 Td
(Bluff,)Tj
2.3754 0 Td
(IL,)Tj
1.321 0 Td
(USA\))Tj
2.4547 0 Td
(and)Tj
1.7348 0 Td
(hemoglobin)Tj
5.0343 0 Td
(with)Tj
2.0013 0 Td
(a)Tj
0.6519 0 Td
(Hemocue)Tj
4.1103 0 Td
(Hb)Tj
1.4966 0 Td
(201)Tj
-32.6038 -1.2983 Td
(+)Tj
0.7993 0 Td
(machine)Tj
3.6624 0 Td
(\(HemoCue)Tj
4.6941 0 Td
(America,)Tj
3.8664 0 Td
(Brea,)Tj
2.2564 0 Td
(CA,)Tj
1.7915 0 Td
(USA\).)Tj
2.6815 0 Td
(Individuals)Tj
4.7225 0 Td
(were)Tj
2.1203 0 Td
(also)Tj
1.7688 0 Td
(excluded)Tj
3.7871 0 Td
(if)Tj
0.7767 0 Td
(they)Tj
1.9219 0 Td
(had)Tj
-34.8489 -1.2983 Td
(taken)Tj
2.4207 0 Td
(medications)Tj
5.0967 0 Td
(that)Tj
1.7801 0 Td
(could)Tj
2.4491 0 Td
(interfere)Tj
3.634 0 Td
(with)Tj
2.0013 0 Td
(test)Tj
1.5987 0 Td
(drug)Tj
2.1147 0 Td
(metabolism)Tj
4.9039 0 Td
(within)Tj
2.8119 0 Td
(one)Tj
1.6951 0 Td
(week)Tj
2.2507 0 Td
(of)Tj
1.0148 0 Td
(study)Tj
-33.7717 -1.3039 Td
(onset)Tj
2.3584 0 Td
(or)Tj
1.0941 0 Td
(if)Tj
0.7767 0 Td
(they)Tj
1.9276 0 Td
(had)Tj
1.7064 0 Td
(evidence)Tj
3.7134 0 Td
(of)Tj
1.0148 0 Td
(urinary)Tj
3.1918 0 Td
(tract)Tj
2.0466 0 Td
(infection)Tj
3.7927 0 Td
(on)Tj
1.2756 0 Td
(a)Tj
0.6519 0 Td
(spun)Tj
2.177 0 Td
(urine)Tj
2.3584 0 Td
(sample)Tj
3.0218 0 Td
(\()Tj
/F16 1 Tf
0 Tc
(>)Tj
/F8 1 Tf
-0.004 Tc
(10)Tj
2.2847 0 Td
(neutro-)Tj
-33.3919 -1.2982 Td
(phils)Tj
2.1373 0 Td
(per)Tj
1.5307 0 Td
(high)Tj
2.0125 0 Td
(powered)Tj
3.6737 0 Td
(field)Tj
1.9729 0 Td
(by)Tj
1.1792 0 Td
(microscopy,)Tj
5.0967 0 Td
(400x\))Tj
2.4548 0 Td
(or)Tj
1.0941 0 Td
(3+)Tj
1.2756 0 Td
(nitrate)Tj
2.863 0 Td
(on)Tj
1.2756 0 Td
(dipstick)Tj
3.3789 0 Td
(\(Diastix,)Tj
3.6169 0 Td
(Bayer)Tj
-33.5619 -1.2983 Td
(Inc.\).)Tj
2.3243 0 Td
(Because)Tj
3.3903 0 Td
(DEC)Tj
2.1883 0 Td
(can)Tj
1.6271 0 Td
(cause)Tj
2.3867 0 Td
(serious)Tj
3.0387 0 Td
(AEs)Tj
1.8369 0 Td
(in)Tj
1.0375 0 Td
(people)Tj
2.8516 0 Td
(infected)Tj
3.4242 0 Td
(with)Tj
1.9956 0 Td
(onchocerciasis)Tj
6.0661 0 Td
([)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(],)Tj
1.5987 0 Td
(all)Tj
1.1452 0 Td
(indi-)Tj
-34.9112 -1.3039 Td
(viduals)Tj
3.0387 0 Td
(were)Tj
2.1203 0 Td
(tested)Tj
2.5511 0 Td
(by)Tj
1.1849 0 Td
(microscopic)Tj
5.108 0 Td
(examination)Tj
5.2327 0 Td
(of)Tj
1.0148 0 Td
(skin)Tj
1.8936 0 Td
(snips)Tj
2.2733 0 Td
(taken)Tj
2.4208 0 Td
(from)Tj
2.2053 0 Td
(both)Tj
2.058 0 Td
(iliac)Tj
1.8595 0 Td
(crests)Tj
2.4605 0 Td
(and)Tj
-35.4215 -1.2983 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.4626 0 Td
(presence)Tj
3.7077 0 Td
(of)Tj
1.0091 0 Td
(antibodies)Tj
4.3597 0 Td
(to)Tj
1.0205 0 Td
(a)Tj
0.6519 0 Td
(recombinant)Tj
/F13 1 Tf
5.3631 0 Td
()Tj
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1452 0 Td
()Tj
/F8 1 Tf
3.4469 0 Td
(antigen)Tj
3.2032 0 Td
(\(Ov16)Tj
2.7099 0 Td
(Rapid)Tj
2.5852 0 Td
(Test,)Tj
2.1316 0 Td
(Standard)Tj
-33.9758 -1.2982 Td
(Diagnostics)Tj
4.8868 0 Td
(Inc.)Tj
1.7575 0 Td
(Youngin,)Tj
3.9402 0 Td
(South)Tj
2.5568 0 Td
(Korea\))Tj
2.9707 0 Td
([)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(].)Tj
2.0749 0 Td
(Persons)Tj
3.3562 0 Td
(with)Tj
1.9956 0 Td
(microfiladermia)Tj
6.6841 0 Td
(or)Tj
1.0998 0 Td
(a)Tj
0.652 0 Td
(positive)Tj
3.3165 0 Td
(Ov16)Tj
-35.2911 -1.304 Td
(antibody)Tj
3.7643 0 Td
(test)Tj
1.5988 0 Td
(\(n)Tj
1.1111 0 Td
(=)Tj
0.7994 0 Td
(3\))Tj
1.0375 0 Td
(were)Tj
2.1203 0 Td
(excluded.)Tj
4.0081 0 Td
(All)Tj
1.4004 0 Td
(participants)Tj
4.9549 0 Td
(signed)Tj
2.8119 0 Td
(a)Tj
0.6577 0 Td
(written)Tj
3.1124 0 Td
(consent)Tj
3.3278 0 Td
(prior)Tj
2.2564 0 Td
(to)Tj
1.0205 0 Td
(screen-)Tj
-33.9815 -1.2982 Td
(ing)Tj
1.5023 0 Td
(and)Tj
1.7291 0 Td
(enrollment)Tj
4.6488 0 Td
(into)Tj
1.8425 0 Td
(the)Tj
1.4684 0 Td
(study.)Tj
ET
Q
q
1 j
1 J
0.0001 w
11.9999 0 0 11.9999 200.012 411.987 cm
BT
/F14 1 Tf
-0.0033 Tc
1 TL
0 0 Td
(Blood)Tj
2.7118 0 Td
(collection)Tj
4.2756 0 Td
(and)Tj
1.7906 0 Td
(assessment)Tj
4.8189 0 Td
(of)Tj
1.0677 0 Td
(adverse)Tj
3.3497 0 Td
(events)Tj
ET
Q
q
1 j
1 J
0.0001 w
10 0 0 10 200.012 394.979 cm
BT
/F8 1 Tf
-0.004 Tc
1 TL
0 0 Td
(Enrollment)Tj
4.7961 0 Td
(began)Tj
2.6022 0 Td
(on)Tj
1.2756 0 Td
(April)Tj
2.3017 0 Td
(17,)Tj
1.4003 0 Td
(2015)Tj
2.1203 0 Td
(and)Tj
1.7292 0 Td
(continued)Tj
4.2916 0 Td
(through)Tj
3.4469 0 Td
(June)Tj
2.0523 0 Td
(4,)Tj
0.9184 0 Td
(2015.)Tj
2.3471 0 Td
(Groups)Tj
3.2201 0 Td
(of)Tj
1.0148 0 Td
(five)Tj
1.6554 0 Td
(par-)Tj
-35.172 -1.2982 Td
(ticipants)Tj
3.6339 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(same)Tj
2.262 0 Td
(sex)Tj
1.4683 0 Td
(were)Tj
2.1203 0 Td
(brought)Tj
3.4243 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(research)Tj
3.5546 0 Td
(center)Tj
2.7099 0 Td
(the)Tj
1.4683 0 Td
(night)Tj
2.3301 0 Td
(prior)Tj
2.2507 0 Td
(to)Tj
1.0261 0 Td
(treatment)Tj
4.1386 0 Td
(for)Tj
-35.3648 -1.2983 Td
(screening)Tj
4.0535 0 Td
(with)Tj
1.9955 0 Td
(baseline)Tj
3.4299 0 Td
(laboratory)Tj
4.3484 0 Td
(tests.)Tj
2.1883 0 Td
(For)Tj
1.6271 0 Td
(men,ultrasound)Tj
6.5876 0 Td
(examinations)Tj
5.5956 0 Td
(were)Tj
2.1203 0 Td
(performed.)Tj
-31.9462 -1.3039 Td
(Investigators)Tj
5.3461 0 Td
(evaluating)Tj
4.3199 0 Td
(AEs)Tj
1.8369 0 Td
(and)Tj
1.7291 0 Td
(performing)Tj
4.8019 0 Td
(ultrasound)Tj
4.5694 0 Td
(examinations)Tj
5.5899 0 Td
(and)Tj
1.7348 0 Td
(laboratory)Tj
4.3483 0 Td
(tests)Tj
-34.2763 -1.2983 Td
(were)Tj
2.1203 0 Td
(blinded)Tj
3.2711 0 Td
(to)Tj
1.0205 0 Td
(participants')Tj
5.176 0 Td
(infection)Tj
3.7927 0 Td
(status.)Tj
2.7213 0 Td
(Participants)Tj
5.0003 0 Td
(remained)Tj
4.0365 0 Td
(at)Tj
0.9524 0 Td
(the)Tj
1.4683 0 Td
(research)Tj
3.5547 0 Td
(center)Tj
-33.1141 -1.2982 Td
(until)Tj
2.1089 0 Td
(72)Tj
1.1679 0 Td
(hours)Tj
2.5171 0 Td
(post-treatment,)Tj
6.3949 0 Td
(then)Tj
2.0183 0 Td
(returned)Tj
3.7134 0 Td
(to)Tj
1.0204 0 Td
(their)Tj
2.109 0 Td
(village)Tj
2.7609 0 Td
(for)Tj
1.3833 0 Td
(passive)Tj
3.0387 0 Td
(follow)Tj
2.6986 0 Td
(up)Tj
1.2643 0 Td
(until)Tj
2.1089 0 Td
(repeat)Tj
-34.3046 -1.2983 Td
(examinations)Tj
5.5898 0 Td
(on)Tj
1.2756 0 Td
(day)Tj
1.6384 0 Td
(7.)Tj
-7.3076 -1.3039 Td
(The)Tj
1.7858 0 Td
(first)Tj
1.8028 0 Td
(treatment)Tj
4.1386 0 Td
(dose)Tj
2.0409 0 Td
(of)Tj
1.0148 0 Td
(triple-drug)Tj
4.5864 0 Td
(therapy)Tj
3.2428 0 Td
(was)Tj
1.7008 0 Td
(given)Tj
2.3811 0 Td
(on)Tj
1.2756 0 Td
(April)Tj
2.3017 0 Td
(18,)Tj
1.4003 0 Td
(2015.)Tj
2.3471 0 Td
(Starting)Tj
3.3788 0 Td
(at)Tj
0.9525 0 Td
(7)Tj
0.6916 0 Td
(a.)Tj
-36.2378 -1.2983 Td
(m.,)Tj
1.491 0 Td
(and)Tj
1.7291 0 Td
(within)Tj
2.8119 0 Td
(about)Tj
2.4945 0 Td
(30)Tj
1.1735 0 Td
(minutes)Tj
3.464 0 Td
(after)Tj
2.0352 0 Td
(eating)Tj
2.6532 0 Td
(a)Tj
0.6577 0 Td
(typical)Tj
2.8629 0 Td
(Ivorian)Tj
3.1408 0 Td
(breakfast)Tj
3.8324 0 Td
(of)Tj
1.0148 0 Td
(wheat)Tj
2.5852 0 Td
(bread)Tj
2.4888 0 Td
(and)Tj
-34.435 -1.2982 Td
(eggs,)Tj
2.1599 0 Td
(all)Tj
1.1452 0 Td
(participants)Tj
4.9606 0 Td
(were)Tj
2.1203 0 Td
(treated)Tj
2.9991 0 Td
(with)Tj
1.9955 0 Td
(a)Tj
0.652 0 Td
(single)Tj
2.5342 0 Td
(co-administered)Tj
6.7691 0 Td
(dose)Tj
2.0409 0 Td
(of)Tj
1.0148 0 Td
(triple-drug)Tj
4.5864 0 Td
(therapy.)Tj
-32.978 -1.304 Td
(Venous)Tj
3.2824 0 Td
(blood)Tj
2.5115 0 Td
(samples)Tj
3.3846 0 Td
(were)Tj
2.1203 0 Td
(collected)Tj
3.7417 0 Td
(at)Tj
0.9524 0 Td
(1,)Tj
0.9184 0 Td
(2,)Tj
0.9241 0 Td
(3,)Tj
0.9184 0 Td
(4,)Tj
0.9241 0 Td
(6,)Tj
0.9185 0 Td
(8,)Tj
0.924 0 Td
(12,)Tj
1.3947 0 Td
(24,)Tj
1.3946 0 Td
(36,)Tj
1.4003 0 Td
(48,)Tj
1.3947 0 Td
(72)Tj
1.1735 0 Td
(hours)Tj
2.5115 0 Td
(and)Tj
1.7291 0 Td
(7)Tj
0.6973 0 Td
(days)Tj
1.9956 0 Td
(after)Tj
-35.2117 -1.2982 Td
(treatment,)Tj
4.3596 0 Td
(with)Tj
1.9956 0 Td
(aliquots)Tj
3.3675 0 Td
(of)Tj
1.0148 0 Td
(plasma)Tj
3.0331 0 Td
(stored)Tj
2.7099 0 Td
(at)Tj
0.9524 0 Td
(-20C)Tj
2.5795 0 Td
(for)Tj
1.3833 0 Td
(later)Tj
1.9956 0 Td
(testing)Tj
2.88 0 Td
(of)Tj
1.0148 0 Td
(drug)Tj
2.1146 0 Td
(levels.)Tj
2.5965 0 Td
(A)Tj
0.9071 0 Td
(peripheral)Tj
-32.9043 -1.2983 Td
(intravenous)Tj
4.9605 0 Td
(catheter)Tj
3.4186 0 Td
(was)Tj
1.7008 0 Td
(placed)Tj
2.7893 0 Td
(for)Tj
1.3889 0 Td
(the)Tj
1.4684 0 Td
(first)Tj
1.8085 0 Td
(12)Tj
1.1678 0 Td
(hours)Tj
2.5172 0 Td
(due)Tj
1.7008 0 Td
(to)Tj
1.0204 0 Td
(frequent)Tj
3.6113 0 Td
(blood)Tj
2.5115 0 Td
(draws.)Tj
2.8233 0 Td
(Additional)Tj
-32.8873 -1.3039 Td
(venous)Tj
3.0387 0 Td
(blood)Tj
2.5171 0 Td
(was)Tj
1.7008 0 Td
(collected)Tj
3.736 0 Td
(between)Tj
3.532 0 Td
(21:30)Tj
2.3471 0 Td
(and)Tj
1.7291 0 Td
(23:00)Tj
2.347 0 Td
(at)Tj
0.9525 0 Td
(39)Tj
1.1735 0 Td
(hours,)Tj
2.7383 0 Td
(7)Tj
0.6973 0 Td
(days)Tj
1.9956 0 Td
(and)Tj
1.7291 0 Td
(1)Tj
0.6973 0 Td
(year)Tj
1.9049 0 Td
(for)Tj
1.3833 0 Td
(Mf)Tj
1.4003 0 Td
(test-)Tj
-35.6199 -1.2983 Td
(ing)Tj
1.491 0 Td
(with)Tj
1.9899 0 Td
(two)Tj
1.7064 0 Td
(1)Tj
0.686 0 Td
(mL)Tj
1.5704 0 Td
(samples)Tj
3.3732 0 Td
(by)Tj
1.1792 0 Td
(membrane)Tj
4.5581 0 Td
(filtration.)Tj
3.9628 0 Td
(Biochemistry)Tj
5.5162 0 Td
(and)Tj
1.7234 0 Td
(urine)Tj
2.3471 0 Td
(tests)Tj
1.9559 0 Td
(were)Tj
2.1146 0 Td
(repeated)Tj
-34.1742 -1.2982 Td
(at)Tj
0.9524 0 Td
(24)Tj
1.1679 0 Td
(and)Tj
1.7347 0 Td
(48)Tj
1.1679 0 Td
(hours)Tj
2.5172 0 Td
(and)Tj
1.7291 0 Td
(7)Tj
0.6973 0 Td
(days)Tj
1.9956 0 Td
(post-treatment.)Tj
-10.7659 -1.3039 Td
(After)Tj
2.2903 0 Td
(treatment,)Tj
4.3597 0 Td
(participants)Tj
4.9549 0 Td
(were)Tj
2.126 0 Td
(monitored)Tj
4.4901 0 Td
(for)Tj
1.3832 0 Td
(AEs)Tj
1.8369 0 Td
(every)Tj
2.3471 0 Td
(6)Tj
0.6973 0 Td
(hours)Tj
2.5115 0 Td
(for)Tj
1.3889 0 Td
(the)Tj
1.4684 0 Td
(first)Tj
1.8028 0 Td
(48)Tj
1.1735 0 Td
(hours,)Tj
-34.0268 -1.2983 Td
(then)Tj
2.0182 0 Td
(every)Tj
2.3471 0 Td
(12)Tj
1.1735 0 Td
(hours)Tj
2.5115 0 Td
(until)Tj
2.109 0 Td
(72)Tj
1.1735 0 Td
(hours,)Tj
2.7382 0 Td
(and)Tj
1.7292 0 Td
(again)Tj
2.3697 0 Td
(at)Tj
0.9524 0 Td
(day)Tj
1.6328 0 Td
(7)Tj
0.6973 0 Td
(post-treatment.)Tj
6.3949 0 Td
(Passive)Tj
3.0841 0 Td
(surveillance)Tj
4.9436 0 Td
(for)Tj
-35.875 -1.2983 Td
(potential)Tj
3.7587 0 Td
(AEs)Tj
1.8368 0 Td
(was)Tj
1.6951 0 Td
(conducted)Tj
4.4277 0 Td
(by)Tj
1.1849 0 Td
(trained)Tj
3.0897 0 Td
(community)Tj
4.8869 0 Td
(health)Tj
2.6759 0 Td
(workers)Tj
3.4356 0 Td
(located)Tj
3.0784 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(participants')Tj
-32.5755 -1.2982 Td
(home)Tj
2.4944 0 Td
(villages)Tj
3.1181 0 Td
(on)Tj
1.2756 0 Td
(days)Tj
2.0012 0 Td
(46.)Tj
1.9106 0 Td
(New)Tj
2.0636 0 Td
(or)Tj
1.0998 0 Td
(worsening)Tj
4.3937 0 Td
(symptoms,)Tj
4.5864 0 Td
(changes)Tj
3.4016 0 Td
(in)Tj
1.0375 0 Td
(vital)Tj
1.9218 0 Td
(signs,)Tj
2.4492 0 Td
(or)Tj
1.0941 0 Td
(new)Tj
1.8765 0 Td
(abnor-)Tj
-34.7241 -1.304 Td
(mal)Tj
1.7177 0 Td
(findings)Tj
3.4923 0 Td
(on)Tj
1.2756 0 Td
(physical)Tj
3.4526 0 Td
(examination)Tj
5.2327 0 Td
(were)Tj
2.1259 0 Td
(considered)Tj
4.5978 0 Td
(to)Tj
1.0262 0 Td
(be)Tj
1.1508 0 Td
(treatment)Tj
4.1329 0 Td
(emergent)Tj
3.9968 0 Td
(adverse)Tj
-32.2013 -1.2982 Td
(events)Tj
2.7269 0 Td
(\(TEAEs\))Tj
3.6963 0 Td
(and)Tj
1.7291 0 Td
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