Nanomedicines towards targeting intracellular Mtb for the treatment of tuberculosis

Donnellan, Samantha ORCID: https://orcid.org/0000-0002-3903-5150 and Giardiello, Marco (2019) 'Nanomedicines towards targeting intracellular Mtb for the treatment of tuberculosis'. Journal of Interdisciplinary Nanomedicine, Vol 4, Issue 3, pp. 76-85.

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Abstract

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), causes the most human deaths than any other diseases from a single infectious agent. Treatments are long and costly and have many associated side effects. Intracellular bacilli are slow growing and difficult to target, which is augmenting the emergence of multi‐drug resistance. A hallmark trait of TB is the formation of granulomas, chronic cellular aggregates, which limit bacterial growth but provides a survival reservoir where bacilli may disseminate from. Targeting intracellular Mtb is challenging, but nanomedicine may offer a solution. Nanomedicine is a significantly growing research area and offers the potential for specific disease targeting, dosage reduction, and intracellular drug delivery. This review discusses the application of the various forms of nanomedicine towards targeting of Mtb.

Item Type:	Article
Subjects:	QT Physiology > QT 4 General works, including comparative physiology QW Microbiology and Immunology > Bacteria > QW 125 Actinibacteria, Actinomycetales. WC Communicable Diseases > Infection. Bacterial Infections > Other Bacterial Infections. Zoonotic Bacterial Infections > WC 302 Actinomycetales infections. Mycobacterium infections WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General)
Faculty: Department:	Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI):	https://doi.org/10.1002/jin2.61
Depositing User:	Stacy Murtagh
Date Deposited:	22 Jul 2019 09:05
Last Modified:	04 Oct 2019 10:35
URI:	https://archive.lstmed.ac.uk/id/eprint/11261

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