LSTM Home > LSTM Research > LSTM Online Archive

Nuclease-based gene drives, an innovative tool for insect vector control: advantages and challenges of the technology

Quinn, Charlotte and Nolan, Tony ORCID: (2020) 'Nuclease-based gene drives, an innovative tool for insect vector control: advantages and challenges of the technology'. Current Opinion in Insect Science, Vol 39, pp. 77-83.

Quinn and Nolan Final Proof for Lib.pdf - Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (944kB) | Preview


Genetic control of insects involves the release of modified insects that contain altered genetic traits and are competent to mate with target populations to introduce the traits therein. Since it relies on mating, this type of control is species-specific, non-toxic, and has the advantage that the released insects can do the difficult task of reaching remote and otherwise inaccessible insect niches.

Gene drives are capable of drastically biasing their own transmission and are being developed as a new type of genetic control, one that would be self-sustaining, requiring low numbers in the initial release in order to spread and persist within a population. In this review, the advantages and challenges of building and deploying this technology will be discussed, using mosquito control as an example.

Item Type: Article
Subjects: QU Biochemistry > Genetics > QU 450 General Works
QX Parasitology > Insects. Other Parasites > QX 500 Insects
QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control
WA Public Health > Preventive Medicine > WA 110 Prevention and control of communicable diseases. Transmission of infectious diseases
Faculty: Department: Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI):
Depositing User: Samantha Sheldrake
Date Deposited: 29 Apr 2020 15:29
Last Modified: 03 Aug 2021 14:04


View details

Actions (login required)

Edit Item Edit Item