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A novel assay of neutrophil extracellular trap (NET) formation identifies anti-IL-8 therapies to reduce disseminated intravascular coagulation and mortality in the intensive care unit

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Abrams, Simon, Morton, Ben ORCID: https://orcid.org/0000-0002-6164-2854, Alhamdi, YasiR, Alsabani, Mohmad, Cheng, Zhenxing, Lane, Steven, Welters, Ingeborg, Wang, Guozheng and Toh, Cheng-Hock (2020) 'A novel assay of neutrophil extracellular trap (NET) formation identifies anti-IL-8 therapies to reduce disseminated intravascular coagulation and mortality in the intensive care unit'. Clinical Medicine, Vol 20, Issue Suppl 2, s114-s115.

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Abstract

Neutrophils are the first line of defence against bacterial infection, and formation of neutrophil extracellular traps (NETs) is an important protective mechanism. NETs can also be harmful by inducing intravascular coagulation and multi-organ failure (MOF) in animal models.1–6 Although increasingly considered as important therapeutic targets,7–9 there is currently no robust and specific measure of NET formation to inform clinical care and enable precision medicine in patients on the intensive care unit (ICU). The aim of this study is to establish a novel assay for measuring NETs and assess its clinical significance.

Item Type: Article
Subjects: WB Practice of Medicine > WB 102 Clinical medicine
WH Hemic and Lymphatic Systems > Hematologic Diseases. Immunologic Factors. Blood Banks > WH 200 Leukocytes. Leukocyte disorders (General)
WX Hospitals and Other Health Facilities > Clinical Departments and Units > WX 200 General works
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.7861/clinmed.20-2-s114
Depositing User: Stacy Murtagh
Date Deposited: 21 May 2020 14:50
Last Modified: 22 May 2020 14:08
URI: https://archive.lstmed.ac.uk/id/eprint/14490

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