Evolution of the insecticide target Rdl in African Anopheles is driven by interspecific and interkaryotypic introgression

Grau-Bové, Xavier, Tomlinson, Sean, O’Reilly, Andrias, Harding, Nicholas, Miles, Alistair, Kwiatkowski, Dominic, Donnelly, Martin ORCID: https://orcid.org/0000-0001-5218-1497 and Weetman, David ORCID: https://orcid.org/0000-0002-5820-1388 (2020) 'Evolution of the insecticide target Rdl in African Anopheles is driven by interspecific and interkaryotypic introgression'. Molecular Biology and Evolution, Vol 37, Issue 10, pp. 2900-2917.

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Abstract

The evolution of insecticide resistance mechanisms in natural populations of Anopheles malaria vectors is a major public health concern across Africa. Using genome sequence data, we study the evolution of resistance mutations in the resistance to dieldrin locus (Rdl), a GABA receptor targeted by several insecticides, but most notably by the long-discontinued cyclodiene, dieldrin. The two Rdl resistance mutations (296G and 296S) spread across West and Central African Anopheles via
two independent hard selective sweeps that included likely compensatory nearby mutations, and were followed by a rare combination of introgression across species (from A. gambiae and A. arabiensis to A. coluzzii) and across non-concordant karyotypes of the 2La chromosomal inversion. Rdl resistance evolved in the 1950s as the first known adaptation to a large-scale insecticidebased intervention, but the evolutionary lessons from this system highlight contemporary and future dangers for management strategies designed to combat development of resistance in malaria vectors.

Item Type:	Article
Corporate Authors:	The Anopheles gambiae 1000 Genomes Consortium (https://www.malariagen.net/projects/ag1000g#people)
Subjects:	QU Biochemistry > Proteins. Amino Acids. Peptides > QU 58 Nucleic acids and derivatives (General) QU Biochemistry > Proteins. Amino Acids. Peptides > QU 58.5 DNA. QX Parasitology > Insects. Other Parasites > QX 515 Anopheles QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control WA Public Health > Preventive Medicine > WA 240 Disinfection. Disinfestation. Pesticides (including diseases caused by)
Faculty: Department:	Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI):	https://doi.org/10.1093/molbev/msaa128
Depositing User:	Luciene Salas Jennings
Date Deposited:	27 May 2020 14:41
Last Modified:	29 Oct 2020 11:01
URI:	https://archive.lstmed.ac.uk/id/eprint/14494

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