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Hill, D. R., Ford, Lisa and Lalloo, David 
ORCID: https://orcid.org/0000-0001-7680-2200
(2006)
'Oral cholera vaccines: use in clinical practice'. Lancet Infectious Diseases, Vol 6, Issue 6, pp. 361-373.
Abstract
Cholera continues to occur globally, particularly in sub-Saharan Africa and Asia. Oral cholera vaccines have been developed and have now been used for several years, primarily in traveller populations. The licensure in the European Union of a killed whole cell cholera vaccine combined with the recombinant B subunit of cholera toxin (rCTB-WC) has stimulated interest in protection against cholera. Because of the similarity between cholera toxin and the heatlabile toxin of Escherichia coli, a cause of travellers' diarrhoea, it has been proposed that the rCTB-WC vaccine may be used against travellers' diarrhoea. An analysis of trials of this vaccine against cholera (serotype 01) shows that for 4-6 months it will protect 61-86% of people living in cholera-endemic regions; lower levels of protection continue for 3 years. Protection wanes rapidly in young children. Because the risk of cholera for most travellers is extremely low, vaccination should be considered only for those working in relief or refugee settings or for those who will be travelling in cholera-epidemic areas and who will be unable to obtain prompt medical care. The vaccine can be expected to prevent 7% or less of cases of travellers' diarrhoea and should not be used for this purpose.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | enterotoxigenic escherichia-coli recombinant-b-subunit whole-cell vaccine states-military personnel heat-labile toxin travelers diarrhea vibrio-cholerae field trial antibody-responses united-states |
| Subjects: | QW Microbiology and Immunology > Immunotherapy and Hypersensitivity > QW 805 Vaccines. Antitoxins. Toxoids QW Microbiology and Immunology > Immunotherapy and Hypersensitivity > QW 806 Vaccination WC Communicable Diseases > Infection. Bacterial Infections > Enteric Infections > WC 262 Cholera |
| Faculty: Department: | Groups (2002 - 2012) > Clinical Group |
| Digital Object Identifer (DOI): | https://doi.org/10.1016/S1473-3099(06)70494-7 |
| Depositing User: | Sarah Lewis-Newton |
| Date Deposited: | 10 May 2011 14:16 |
| Last Modified: | 06 Feb 2018 13:01 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/1505 |
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