Long term outcomes for elderly patients after emergency intensive care admission: A cohort study

Dempsey, Jed, Hungerford, Dan, McHale, Phil, McGarey, Lauren, Benison, Edward and Morton, Ben ORCID: https://orcid.org/0000-0002-6164-2854 (2020) 'Long term outcomes for elderly patients after emergency intensive care admission: A cohort study'. PLoS ONE, Vol 15, Issue 10, e0241244.

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Abstract

Background
Elderly patients (≥ 80 years of age) surviving an episode of critical illness suffer long-term morbidity and risk of mortality. Identifying high risk groups could assist in informing discussions with patients and families.
Aim
To determine factors associated with long-term survival following ICU admission.
Design
A cohort study of patients aged ≥ 80 years of age admitted to the ICU as an emergency.
Methods
Patients admitted from January 2010 to December 2018 were included in the study. Primary outcome was five year survival. Mortality was assessed using a multivariable flexible parametric survival analysis adjusted for demographics, and clinically relevant covariates.

Results
There were 828 patients. Mean age was 84 years (SD 3.2) and 419 (51%) were male. Patients were categorised into medical (423 (51%)) and surgical (405 (49%)) admissions. Adjusted hazard ratios (aHR) for mortality were highest for serum lactate (>8 mmol/l aHR 2.56 (C.I. 1.79–3.67)), lowest systolic blood pressure (< 70 mmHg aHR 2.04 (C.I. 1.36–3.05)) and pH (< 7.05 aHR 4.70 (C.I 2.67–8.21)). There were no survivors beyond one year with severe abnormalities of pH and lactate (< 7.05 and > 8 mmol/l respectively). Relative survival for medical patients was below that expected for the general population for the duration of the study.
Conclusion
Overall five-year survival was 27%. For medical and surgical patients it was 19% and 35% respectively. Survival at 30 days and one year was 61% and 46%. The presence of features of circulatory shock predicted poor short and long term survival.

Item Type:	Article
Subjects:	WT Geriatrics. Chronic Disease > Geriatrics > WT 100 General works WT Geriatrics. Chronic Disease > Geriatrics > WT 116 Longevity. Life expectancy. Death WX Hospitals and Other Health Facilities > Clinical Departments and Units > WX 200 General works
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1371/journal.pone.0241244
Depositing User:	Debbie Jenkins
Date Deposited:	10 Nov 2020 11:04
Last Modified:	10 Nov 2020 11:04
URI:	https://archive.lstmed.ac.uk/id/eprint/16051

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