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Global Burden of Invasive Nontyphoidal Salmonella Disease, 2010

Ao, Trong T., Feasey, Nicholas ORCID:, Gordon, Melita A., Keddy, Karen H., Angulo, Frederick J. and Crump, John A. (2015) 'Global Burden of Invasive Nontyphoidal Salmonella Disease, 2010'. Emerging Infectious Diseases, Vol 21, Issue 6, pp. 941-949.

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Nontyphoidal Salmonella is a major cause of bloodstream infections worldwide, and HIV-infected persons and malaria-infected and malnourished children are at increased risk for the disease. We conducted a systematic literature review to obtain age group–specific, population-based invasive nontyphoidal Salmonella (iNTS) incidence data. Data were categorized by HIV and malaria prevalence and then extrapolated by using 2010 population data. The case-fatality ratio (CFR) was determined by expert opinion consensus. We estimated that 3.4 (range 2.1–6.5) million cases of iNTS disease occur annually (overall incidence 49 cases [range 30–94] per 100,000 population). Africa, where infants, young children, and young adults are most affected, had the highest incidence (227 cases [range 152–341] per 100,000 population) and number of cases (1.9 [range 1.3–2.9] million cases). An iNTS CFR of 20% yielded 681,316 (range 415,164–1,301,520) deaths annually. iNTS disease is a major cause of illness and death globally, particularly in Africa. Improved understanding of the epidemiology of iNTS is needed.

Item Type: Article
Subjects: WC Communicable Diseases > Infection. Bacterial Infections > Enteric Infections > WC 269 Salmonella infections
Digital Object Identifer (DOI):
Depositing User: Stacy Murtagh
Date Deposited: 08 Dec 2020 13:43
Last Modified: 08 Dec 2020 13:43


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