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Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.

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O'Neill, Paul M, Amewu, Richard K, Nixon, Gemma L, Bousejra ElGarah, Fatima, Mungthin, Mathirut, Chadwick, James, Shone, Alison, Vivas, Livia, Lander, Hollie, Barton, Victoria, Muangnoicharoen, Sant, Bray, Patrick, Davies, Jill, Park, B Kevin, Wittlin, Sergio, Brun, Reto, Preschel, Michael, Zhang, Kesheng and Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 (2010) 'Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.'. Angewandte Chemie (International ed. in English), Vol 49, Issue 33, pp. 5693-7.

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/anie.20...

Item Type:	Article
Uncontrolled Keywords:	antimalarial agents;drug development;endoperoxides;medicinal chemistry;tetraoxanes
Subjects:	QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 256 Antimalarials
Faculty: Department:	Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI):	https://doi.org/10.1002/anie.201001026
Depositing User:	Mary Creegan
Date Deposited:	17 Nov 2010 12:34
Last Modified:	17 Jul 2020 10:57
URI:	https://archive.lstmed.ac.uk/id/eprint/1686

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