Mosquito age and susceptibility to insecticides

Rajatileka, Shavanthi, Burhani, Joseph and Ranson, Hilary ORCID: https://orcid.org/0000-0003-2332-8247 (2011) 'Mosquito age and susceptibility to insecticides'. Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol 105, Issue 5, pp. 247-253.

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Abstract

Insecticides play a crucial role in controlling the transmission of mosquito-borne diseases and the development and spread of insecticide resistance is a major threat to sustainable control. Guidelines developed by the WHO to monitor for insecticide resistance recommend using 1-3 day old, non blood fed female mosquitoes. This standardisation facilitates comparison between different tests, which is important when monitoring for spatial or longitudinal variations in resistance in the field. However, mosquitoes of this age cannot transmit human pathogens. In order to transmit disease, the mosquito must live long enough to pick up the pathogen via a blood meal, survive the extrinsic incubation period and then pass on the pathogen during a subsequent blood meal. Previous studies have reported declines in insecticide resistance with mosquito age. If widely applicable this would have important implications for predictions of the impact of resistance that are based on results from WHO bioassays. This study investigated the impact of senescence and blood feeding on insecticide induced mortality in six different mosquito populations and found higher mortality after insecticide exposure in older mosquitoes in three populations of Aedes aegypti and two Anopheles gambiae populations. Age dependent changes in the expression of a known insecticide detoxification gene, GSTe2, and in the frequency of a target site mutation (kdr 1014F) were investigated in an attempt to explain the results.

Item Type:	Article
Uncontrolled Keywords:	Insecticide resistance; Malaria; Dengue; Senescence; Kdr; Bioassay
Subjects:	QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control QX Parasitology > Insects. Other Parasites > QX 650 Insect vectors
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.trstmh.2011.01.009
Depositing User:	Users 183 not found.
Date Deposited:	28 Apr 2011 12:48
Last Modified:	29 Nov 2024 12:33
URI:	https://archive.lstmed.ac.uk/id/eprint/1757

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