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Reduced interleukin-8 response to Streptococcus pneumoniae by alveolar macrophages from adults with HIV/AIDS

Gordon, Stephen ORCID:, Jarman, E. R., Kanyanda, S., French, Neil, Pridmore, A. C., Zijlstra, E. E., Molyneux, Malcolm E and Read, R. C. (2005) 'Reduced interleukin-8 response to Streptococcus pneumoniae by alveolar macrophages from adults with HIV/AIDS'. AIDS, Vol 19, Issue 11, pp. 1197-1200.

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Background: HIV-infected adults are highly susceptible to pneumococcal disease.
Objective: To examine if alveolar macrophages from HIV-infected subjects exhibited a failure of cytokine production in response to Streptococcus pneumoniae in vitro.
Design: Case-control comparison of alveolar macrophages from 11 HIV-infected and 13 non-infected adults.
Methods: Type I opsonized S. pneumoniae were used to challenge the alveolar macrophages in vitro. Cell supernatant fluid was collected from unstimulated cells, and cells challenged with bacteria for 0, 6, 12 and 24 h. Cytokine production (interleukins 1 beta, 6 and 8) was measured in all fluids using an enzyme-linked immunosorbent assay.
Results: All the cytokines tested increased over time in both HIV-infected and uninfected subjects. Interleukin-8 release was significantly lower in HIV-infected than in non-HIV-infected subjects (P = 0.02).
Conclusion: Reduced interleukin-8 production may result in decreased neutrophil recruitment, and hence increased susceptibility to pneumococcal infection in HIV-infected subjects. (c) 2005 Lippincott Williams & Wilkins.

Item Type: Article
Subjects: WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 204 Pneumococcal pneumonia. Staphylococcal pneumonia
WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.5 Complications
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Depositing User: Ms Julia Martin
Date Deposited: 28 Sep 2011 12:00
Last Modified: 17 Jul 2020 10:58


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