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Prevalence of intestinal schistosomiasis in pre-school aged children: a pilot survey in Marolambo District, Madagascar

Sheehy, Caitlin, Lawson, Heather, Andriamasy, Emmanuel H., Russell, Hannah J., Reid, Alice, Raderalazasoa, Gina U., Dodge, Graham, Kornitschky, Robbie, Penney, James M. StJ., Ranaivoson, Tahiry N., Andrianiaina, Antsa, Emmanoela, Jenny S., Bustinduy, Amaya L., Stothard, Russell ORCID:, Andrianjaka, Louis and Spencer, Stephen A. (2021) 'Prevalence of intestinal schistosomiasis in pre-school aged children: a pilot survey in Marolambo District, Madagascar'. Infectious Diseases of Poverty, Vol 10, Issue 87.

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School-aged children (SAC) have a considerable burden of intestinal schistosomiasis in Madagascar yet its burden
in pre-school aged children (PSAC) is currently overlooked. To assess the at-risk status of PSAC, we undertook a pilot
epidemiological survey in June 2019 examining children (n = 89), aged 2–4-years of balanced gender, in six remote
villages in Marolambo District, Madagascar. Diagnosis included use of urine-circulating cathodic antigen (CCA) dipsticks
and coproscopy of stool with duplicate Kato-Katz (K-K) thick smears. Prevalence of intestinal schistosomiasis by
urine-CCA was 67.4% (95% confidence interval [CI]: 56.5–77.2%) and 35.0% (95% CI: 24.7–46.5%) by K-K. The relationship
between faecal eggs per gram (epg) and urine-CCA G-scores (G1 to G10) was assessed by linear regression modelling,
finding for every increment in G-score, epg increased by 20.4 (6.50–34.4, P = 0.006). Observed proportions of
faecal epg intensities were light (78.6%), moderate (17.9%) and heavy (3.6%). Soil-transmitted helminthiasis was noted,
prevalence of ascariasis was 18.8% and trichuriasis was 33.8% (hookworm was not reported). Co-infection of intestinal
schistosomiasis and soil-transmitted helminthiasis occurred in 36.3% of PSAC. These results provide solid evidence
highlighting the overlooked burden of intestinal schistosomiasis in PSAC, and they also offer technical guidance for
better surveillance data for the Madagascan national control programme.

Item Type: Article
Subjects: WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WA Public Health > Statistics. Surveys > WA 900 Public health statistics
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 810 Schistosomiasis
WS Pediatrics > WS 100 General works
WS Pediatrics > Diseases of Children and Adolescents > By System > WS 310 Digestive system
Faculty: Department: Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI):
Depositing User: Marie Hatton
Date Deposited: 05 Aug 2021 09:17
Last Modified: 05 Aug 2021 09:17


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