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Thirteen-Valent Pneumococcal Conjugate Vaccine–Induced Immunoglobulin G (IgG) Responses in Serum Associated With Serotype-Specific IgG in the Lung

Mitsi, Elena, McLenaghan, Daniella, Wolf, Asia-Sophia, Jones, Scott, Collins, Andrea ORCID: https://orcid.org/0000-0002-4094-1572, Hyder-Wright, Angela, Goldblatt, David, Heyderman, Robert, Gordon, Stephen ORCID: https://orcid.org/0000-0001-6576-1116 and Ferreira, Daniela ORCID: https://orcid.org/0000-0002-0594-0902 (2021) 'Thirteen-Valent Pneumococcal Conjugate Vaccine–Induced Immunoglobulin G (IgG) Responses in Serum Associated With Serotype-Specific IgG in the Lung'. Journal of Infectious Disease. (In Press)

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Abstract

Pneumococcal conjugate vaccine (PCV) efficacy is lower for
noninvasive pneumonia than invasive disease. In this study,
participants were immunized with 13-valent PCV (PCV13) or
hepatitis A vaccine (control). Bronchoalveolar lavage samples
were taken between 2 and 6 months and serum at 4 and 7 weeks
postvaccination. In the lung, anti-capsular immunoglobulin G
(IgG) levels were higher in the PCV13 group compared to controls for all serotypes, except 3 and 6B. Systemically, IgG levels
were elevated in the PCV13 group at 4 weeks for all serotypes,
except serotype 3. IgG in bronchoalveolar lavage and serum
positively correlated for nearly all serotypes. PCV13 shows
poor immunogenicity to serotype 3, implying lack of protective
efficacy.

Item Type: Article
Subjects: QW Microbiology and Immunology > Bacteria > QW 142 Gram-positive bacteria (General)
QW Microbiology and Immunology > Antigens and Antibodies. Toxins and Antitoxins > QW 575 Antibodies
QY Clinical Pathology > QY 4 General works
WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 217 Pneumococcal infections
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1093/infdis/jiab331
Depositing User: Julie Franco
Date Deposited: 19 Aug 2021 14:08
Last Modified: 19 Aug 2021 14:08
URI: https://archive.lstmed.ac.uk/id/eprint/18691

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