Dengue infection during pregnancy and transplacental antibody transfer in Thai mothers

Perret, C., Chanthavanich, P., Pengsaa, K., Limkittikul, K., Hutajaroen, P., Bunn, J. and Brabin, Bernard (2005) 'Dengue infection during pregnancy and transplacental antibody transfer in Thai mothers'. Journal of Infection, Vol 51, Issue 4, pp. 287-293.

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Abstract

Objectives. The objectives of this study were to estimate dengue seroprevalence in a population of Thai pregnant women, Living in a highly endemic area and placental transfer of dengue antibodies.
Methods. A cross-sectional seroprevalence study of 245 pregnant women at delivery.
Results. Dengue HAI antibodies were positive in 94.7%. Maternal age was the only risk factor associated with dengue infection as older mothers (>20 years) were significantly more likely to be seropositive than younger women (p<0.0001). Cord antibody titres varied with maternal age and antibody titre, were significantly higher in babies born to younger mothers (<20 years) (p=0.01), and were significantly correlated with maternal titre. Low birthweight babies had Lower transfer ratios for DEN-2 antibody (1.06) compared to heavier babies (1.36, p=0.05). No mother or neonate had dengue IgM detected. Two women were classified as recently, but not currently infected with dengue virus and we consider it likely these were first trimester infections. As no infant became infected the fetal infection was 0%.
Conclusions. Younger mothers were more likely to have been recently infected, resulting in higher antibody titres. Maternal dengue antibody transfer was proportional to maternal antibody concentration. (C) 2004 The British Infection Society. Published by Elsevier Ltd. All rights reserved.

Item Type:	Article
Uncontrolled Keywords:	dengue antibodies pregnancy transplacental transfer congenital infection hemorrhagic-fever vertical transmission fc-receptors epidemiology
Subjects:	WC Communicable Diseases > Virus Diseases > Infectious Mononucleosis. Arbovirus Infections > WC 528 Dengue WQ Obstetrics > Pregnancy Complications > WQ 256 Infectious diseases
Faculty: Department:	Groups (2002 - 2012) > Child & Reproductive Health Group
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.jinf.2004.10.003
Depositing User:	Ms Julia Martin
Date Deposited:	29 Jul 2011 14:34
Last Modified:	06 Feb 2018 13:02
URI:	https://archive.lstmed.ac.uk/id/eprint/1917

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