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Reynolds-Wright, John J, Woldetsadik, Mulat A, Morroni, Chelsea 
ORCID: https://orcid.org/0000-0002-2026-6039 and Cameron, Sharon
(2022)
'Pain management for medical abortion before 14 weeks' gestation.'. Cochrane Database of Systematic Reviews, Vol 5, CD013525.
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Reynolds-Wright_et_al-2022-Cochrane_Database_of_Systematic_Reviews.pdf - Published Version Download (1MB) | Preview |
Abstract
Background
Abortion is common worldwide and increasingly abortions are performed at less than 14 weeks’ gestation using medical methods, specifically using a combination of mifepristone and misoprostol. Medical abortion is known to be a painful process, but the optimal method of pain management is unclear. We sought to identify and compare pain management regimens for medical abortion before 14 weeks’ gestation.
Objectives
Primary objective
To determine if there is evidence of superiority of any particular pain relief regimen in the management of combination medical abortion (mifepristone + misoprostol) under 14 weeks' gestation (i.e. up to 13 + 6 weeks or 97 days).
Secondary objectives
To compare the rate of gastrointestinal side effects resulting from different methods of analgesia
To compare the rate of complete abortion resulting from different methods of analgesia during medical abortion
To determine if the induction‐to‐abortion interval is associated with different methods of analgesia
To determine if any method of analgesia is associated with unscheduled contact with the care provider in relation to pain.
Search methods
On 21 August 2019 we searched CENTRAL, MEDLINE, Embase, CINAHL, LILACs, PsycINFO, the World Health Organization International Clinical Trials Registry and ClinicalTrials.gov together with reference checking and handsearching of conference abstracts of relevant learned societies and professional organisations to identify further studies.
Selection criteria
We included randomised controlled trials (RCTs) and observational studies (non‐randomised studies of interventions (NRSIs)) of any pain relief intervention (pharmacological and non‐pharmacological) for mifepristone‐misoprostol combination medical abortion of pregnancies less than 14 weeks’ gestation.
Data collection and analysis
Two review authors (JRW and MA) independently assessed all identified papers for inclusion and risks of bias, resolving any discrepancies through discussion with a third and fourth author as required (CM and SC). Two review authors independently conducted data extraction, including calculations of pain relief scores, and checked for accuracy. We assessed the certainty of the evidence using the GRADE approach.
Main results
We included four RCTs and one NRSI. Due to the heterogeneity of study designs, interventions and outcome reporting, we were unable to perform meta‐analysis for any of the primary or secondary outcomes in this review.
Only one study found evidence of an effect between interventions on pain score: a prophylactic dose of ibuprofen 1600 mg likely reduces the pain score when compared to a dose of paracetamol 2000 mg (mean difference (MD) 2.26 out of 10 lower, 95% confidence interval (CI) 3.00 to 1.52 lower; 1 RCT 108 women; moderate‐certainty evidence).
There may be little to no difference in pain score when comparing pregabalin 300 mg with placebo (MD 0.5 out of 10 lower, 95% CI 1.41 lower to 0.41 higher; 1 RCT, 107 women; low‐certainty evidence).
There may be little to no difference in pain score when comparing ibuprofen 800 mg with placebo (MD 1.4 out of 10 lower, 95% CI 3.33 lower to 0.53 higher; 1 RCT, 61 women; low‐certainty evidence).
Ambulation or non‐ambulation during medical abortion treatment may have little to no effect on pain score, but the evidence is very uncertain (MD 0.1 out of 5 higher, 95% CI 0.26 lower to 0.46 higher; 1 NRSI, 130 women; very low‐certainty evidence).
There may be little to no difference in pain score when comparing therapeutic versus prophylactic administration of ibuprofen 800 mg (MD 0.2 out of 10 higher, 95% CI 0.41 lower to 0.81 higher; 1 RCT, 228 women; low‐certainty evidence).
Other outcomes of interest were reported inconsistently across studies. Where these outcomes were reported, there was no evidence of difference in incidence of gastrointestinal side effects, complete abortion rate, interval between misoprostol administration to pregnancy expulsion, unscheduled contact with a care provider, patient satisfaction with analgesia regimen nor patient satisfaction with abortion experience overall. However, the certainty of evidence was very low to low.
| Item Type: | Article |
|---|---|
| Subjects: | WA Public Health > Health Problems of Special Population Groups > WA 309 Women's health WQ Obstetrics > WQ 20 Research (General) WQ Obstetrics > Pregnancy > WQ 200 General works |
| Faculty: Department: | Clinical Sciences & International Health > Clinical Sciences Department Clinical Sciences & International Health > International Public Health Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1002/14651858.CD013525.pub2 |
| SWORD Depositor: | JISC Pubrouter |
| Depositing User: | JISC Pubrouter |
| Date Deposited: | 07 Sep 2022 15:12 |
| Last Modified: | 13 May 2023 01:02 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/20494 |
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