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Time to Clinical Benefit of Intensive Blood Pressure Lowering in Patients 60 Years and Older With Hypertension A Secondary Analysis of Randomized Clinical Trials

Chen, Tao ORCID:, Shao, Fang, Chen, Kangyu, Wang, Yang, Wu, Zhenqiang, Wang, Yongjuan, Gao, Yanpei, Cornelius, Victoria, Li, Chao and Jiang, Zhixin (2022) 'Time to Clinical Benefit of Intensive Blood Pressure Lowering in Patients 60 Years and Older With Hypertension A Secondary Analysis of Randomized Clinical Trials'. JAMA Internal Medicine, Vol 182, Issue 6, pp. 660-667.

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Recent guidelines recommend a systolic blood pressure (BP) goal of less than 150 mm Hg or even 130 mm Hg for adults aged 60 years or older. However, harms from intensive BP treatments occur immediately (eg, syncope, fall), and benefits for cardiovascular event reduction emerge over time. Therefore, harms with low chance of benefit need to be clearer, particularly for those with limited life expectancy.

To estimate the time needed to potentially derive clinical benefit from intensive BP treatment in patients 60 years and older.

Design, Setting, and Participants
This secondary analysis included individual patient data from published randomized clinical trials with 27 414 patients 60 years or older with hypertension. Patient-level survival data were reconstructed when the original data were not available. Published trials were identified by searching PubMed until October 15, 2021.

Intensive BP lowering vs standard BP lowering with the treat-to-target design.

Main Outcomes and Measures
Major adverse cardiovascular event (MACE) defined by each trial, which was broadly similar with all trials including myocardial infarction, stroke, and cardiovascular mortality.

Six trials (original data from 2 trials and reconstructed data from 4 trials) with 27 414 participants (mean age, 70 years; 56.3% were women) were included in the analysis. Intensive BP treatment with a systolic BP target below 140 mm Hg was significantly associated with a 21% reduction in MACE (hazard ratio, 0.79; 95% CI, 0.71-0.88; P < .001). On average, 9.1 (95% CI, 4.0-20.6) months were needed to prevent 1 MACE per 500 patients with the intensive BP treatment (absolute risk reduction [ARR], 0.002). Likewise, 19.1 (95% CI, 10.9-34.2) and 34.4 (95% CI, 22.7-59.8) months were estimated to avoid 1 MACE per 200 (ARR, 0.005) and 100 (ARR, 0.01) patients, respectively.

Conclusions and Relevance
In this analysis, findings suggest that for patients 60 years and older with hypertension, intensive BP treatment may be appropriate for some adults with a life expectancy of greater than 3 years but may not be suitable for those with less than 1 year.

Item Type: Article
Subjects: WA Public Health > Preventive Medicine > WA 108 Preventive health services. Preventive medicine. Travel Medicine.
WG Cardiovascular System > WG 20 Research (General)
WT Geriatrics. Chronic Disease > Geriatrics > WT 100 General works
WT Geriatrics. Chronic Disease > Geriatrics > WT 104 Aging process
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):
SWORD Depositor: JISC Pubrouter
Depositing User: JISC Pubrouter
Date Deposited: 21 Sep 2022 12:43
Last Modified: 21 Sep 2022 12:43


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