Obesity, leptin and host defence of Streptococcus pneumoniae: the case for more human research

Hales, Caz, Burnet, Laura, Coombs, Maureen, Collins, Andrea ORCID: https://orcid.org/0000-0002-4094-1572 and Ferreira, Daniela ORCID: https://orcid.org/0000-0002-0594-0902 (2022) 'Obesity, leptin and host defence of Streptococcus pneumoniae: the case for more human research'. European Respiratory Review, Vol 31, Issue 165, e22055.

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Abstract

Pneumococcal pneumonia is the leading cause of community-acquired pneumonia. Obesity is a risk factor for pneumonia. Host factors play a critical role in susceptibility to pulmonary pathogens and outcome from pulmonary infections. Obesity impairs innate and adaptive immune responses, important in the host defence against pneumococcal disease. One area of emerging interest in understanding the complex relationship between obesity and pulmonary infections is the role of the hormone leptin. There is a substantive evidence base supporting the associations between obesity, leptin, pulmonary infections and host defence mechanisms. Despite this, there is a paucity of research that specifically focuses on (pneumococcal) infections, which are the leading cause of community-acquired pneumonia hospitalisations and mortality worldwide. Much of the evidence examining the role of leptin in relation to infections has used genetically mutated mice. The purpose of this mini review is to explore the role leptin plays in the host defence of in subjects with obesity and posit an argument for the need for more human research.

Item Type:	Article
Subjects:	WC Communicable Diseases > WC 20 Research (General) WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 210 Streptococcal infections (General or not elsewhere classified)
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1183/16000617.0055-2022
SWORD Depositor:	JISC Pubrouter
Depositing User:	JISC Pubrouter
Date Deposited:	12 Oct 2022 14:38
Last Modified:	13 Jun 2023 11:24
URI:	https://archive.lstmed.ac.uk/id/eprint/21106

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