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Airway-resident T cells from unexposed individuals cross-recognize SARS-CoV-2.

Diniz, Mariana O, Mitsi, Elena, Swadling, Leo, Rylance, Jamie ORCID:, Johnson, Marina, Goldblatt, David, Ferreira, Daniela ORCID: and Maini, Mala K (2022) 'Airway-resident T cells from unexposed individuals cross-recognize SARS-CoV-2.'. Nature Immunology, Vol 23, Issue 9, pp. 1324-1329.

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T cells can contribute to clearance of respiratory viruses that cause acute-resolving infections such as SARS-CoV-2, helping to provide long-lived protection against disease. Recent studies have suggested an additional role for T cells in resisting overt infection: pre-existing cross-reactive responses were preferentially enriched in healthcare workers who had abortive infections<sup>1</sup>, and in household contacts protected from infection<sup>2</sup>. We hypothesize that such early viral control would require pre-existing cross-reactive memory T cells already resident at the site of infection; such airway-resident responses have been shown to be critical for mediating protection after intranasal vaccination in a murine model of SARS-CoV<sup>3</sup>. Bronchoalveolar lavage samples from the lower respiratory tract of healthy donors obtained before the COVID-19 pandemic revealed airway-resident, SARS-CoV-2-cross-reactive T cells, which correlated with the strength of human seasonal coronavirus immunity. We therefore demonstrate the potential to harness functional airway-resident SARS-CoV-2-reactive T cells in next-generation mucosal vaccines.

Item Type: Article
Subjects: QU Biochemistry > Cells and Genetics > QU 350 Cellular structures
WC Communicable Diseases > Virus Diseases > Viral Respiratory Tract Infections. Respirovirus Infections > WC 506 COVID-19
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):
SWORD Depositor: JISC Pubrouter
Depositing User: JISC Pubrouter
Date Deposited: 13 Oct 2022 13:58
Last Modified: 13 Oct 2022 13:58


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