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Dhabangi, Aggrey, Ssenyonga, Ronald, Siu, Godfrey, Elaborot, Susan Acana, Kyeyune, Dorothy and Bates, Imelda 
ORCID: https://orcid.org/0000-0002-0862-8199
(2023)
'Iron deficiency in whole blood donors in a resource-poor setting: A cross-sectional study in Uganda'. Transfusion Medicine, Vol 33, Issue 3, pp. 213-220.
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Abstract
Background and Objective
Blood donation is known to result in iron deficiency (ID), with a higher prevalence in females. There is little published data on the frequency of ID among blood donors in resource-poor settings. We determined the prevalence of ID in blood donors in Uganda.
Methods
We conducted a descriptive cross-sectional study at the Uganda Blood Transfusion Service, Kampala from December 2021 to February 2022. A sample of 500 whole blood donors was enrolled. The evaluation included demographic characteristics, donation history, nutritional history, complete blood count, and serum ferritin. The primary outcome was the proportion of donors with serum ferritin <15 μg/L.
Results
The median (IQR) serum ferritin was 25 (12–47) μg/L and 89 (52–133) μg/L among female and male donors respectively. The prevalence of iron deficiency (serum ferritin <15 μg/L) among donating individuals was 11.5% (8.7–14.9), while among low haemoglobin deferrals, 61.5% (50.9–71.1). The prevalence was high among females [33.0% (27.9–38.6)] compared with males [2.5% (1.0–5.8)], but even higher among females younger than 24 years [35.4% (29.2–42.1)]. Factors associated with ID (adjusted odds ratio, 95% Cl, and significance) were; female donors (15.81, 5.17, 48.28, p < 0.001) and a high RDW (6.89, 2.99, 15.90, p < 0.001). We found a moderate correlation between serum ferritin and RDW (r = −0.419 and −0.487 for males and females respectively).
Conclusion
Iron deficiency is common among blood donors in Uganda, affecting mostly young female donors. Considerations to adopt evidence-based strategies to prevent and manage ID among blood donors–such as serum ferritin monitoring and iron supplementation are highly recommended.
| Item Type: | Article |
|---|---|
| Subjects: | QV Pharmacology > Hematologic Agents > QV 183 Iron. Iron compounds WA Public Health > WA 30 Socioeconomic factors in public health (General) WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Nutrition Disorders > WD 105 Deficiency diseases WH Hemic and Lymphatic Systems > WH 20 Research (General) WH Hemic and Lymphatic Systems > Hematologic Diseases. Immunologic Factors. Blood Banks > WH 460 Blood bank procedures |
| Faculty: Department: | Clinical Sciences & International Health > International Public Health Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1111/tme.12953 |
| SWORD Depositor: | JISC Pubrouter |
| Depositing User: | JISC Pubrouter |
| Date Deposited: | 14 Mar 2023 15:13 |
| Last Modified: | 26 Jan 2024 04:12 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/21911 |
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