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Polyuria in association with Plasmodium falciparum malaria in a region of unstable transmission

Grimwade, Kate, French, Neil, Mthembu, D. and Gilks, C.F. (2004) 'Polyuria in association with Plasmodium falciparum malaria in a region of unstable transmission'. Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol 98, Issue 4, pp. 255-260.

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During a recent epidemic of Plasmodium falciparum malaria in Hlabisa district, KwaZulu Natal, polyuria was recognized in a subset of adults presenting to hospital with severe disease. In January to May 2000, following consent, cases of severe malaria provided blood spots for HIV testing, clinical data, and blood and urine samples for investigation of the polyuria. Four hundred and eleven adults with malaria were admitted, of whom 175 had severe malaria and 37 had polyuria (21% of severe cases). In those with polyuria the mean 24-h urine output was 3018 ml or 2.85 ml/kg/h. Ten of 15 (66%) patients investigated had urine and plasma osmolalities consistent with diabetes insipidus. There was no significant association between polyuria and sex, age, HIV status or features of severe malaria. Whether the polyuria in these non-immune adults is a localized problem unrelated to malaria, or a hitherto unrecognized complication of severe malaria is not clear. Physicians are alerted to this observation, and the need for more clinical and pathophysiological studies. (C) 2004 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

Item Type: Article
Uncontrolled Keywords: malaria plasmodium falciparum polyuria renal impairment africa children
Subjects: QX Parasitology > Protozoa > QX 135 Plasmodia
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
WJ Urogenital System > WJ 146 Urination and urination disorders
Digital Object Identifer (DOI):
Depositing User: Martin Chapman
Date Deposited: 20 Dec 2012 15:55
Last Modified: 21 Nov 2019 15:04


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