A neglected among the neglected: a review of cutaneous leishmaniasis in Guatemala

Lopez, Yaimie, Arana, Byron, Rizzo, Nidia, Duran, Erick, Acosta-Serrano, Alvaro ORCID: https://orcid.org/0000-0002-2576-7959 and Mendizabal-Cabrera, Renata (2023) 'A neglected among the neglected: a review of cutaneous leishmaniasis in Guatemala'. Transactions of The Royal Society of Tropical Medicine and Hygiene, Vol 117, Issue 9, pp. 609-616.

Text Manuscript-Leishmaniasis-in-Guatemala.pdf - Accepted Version Restricted to Repository staff only until 27 April 2024. Download (1MB)

Abstract

Cutaneous leishmaniasis (CL) is a parasitic vector-borne disease affecting mostly low- and middle-income countries. CL is endemic in Guatemala, where an increase in the number of cases and incidence and a changing disease distribution in the past decade have been reported. Important research was conducted in Guatemala in the 1980s and 1990s to understand the epidemiology of CL and two Leishmania species were identified as the aetiologic agents. Several species of sand flies have been reported, five of which are naturally infected with Leishmania. Clinical trials conducted in the country evaluated different treatments against the disease and provided solid evidence for CL control strategies that are applicable worldwide. More recently, in the 2000s and 2010s, qualitative surveys were conducted to understand community perceptions of the disease and to highlight the challenges and enablers for disease control. However, limited recent data have been generated regarding the current CL situation in Guatemala, and key information necessary for effective disease control, such as incrimination of vectors and reservoirs, is still lacking. This review describes the current state of knowledge of CL in Guatemala, including the main parasite and sand fly species, disease reservoirs, diagnosis and control, as well as the perceptions of communities in endemic regions.

Item Type:	Article
Subjects:	WC Communicable Diseases > Tropical and Parasitic Diseases > WC 680 Tropical diseases (General) WR Dermatology > Parasitic Skin Diseases > WR 350 Tropical diseases of the skin. Mucocutaneous leishmaniasis. Leishmaniasis
Faculty: Department:	Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI):	https://doi.org/10.1093/trstmh/trad024
SWORD Depositor:	JISC Pubrouter
Depositing User:	JISC Pubrouter
Date Deposited:	11 May 2023 13:12
Last Modified:	10 Oct 2023 13:07
URI:	https://archive.lstmed.ac.uk/id/eprint/22458

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