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Luty, Adrian J.F., Baiden, Frank, Fleck, Suzanne, Leigh, Bailah, Ayieko, Philip, Tindanbil, Daniel, Otieno, Tuda, Lawal, Bolarinde, Tehtor, Mattu, Rogers, Maariam, Odeny, Lazarus, Hodges, Mary H., Sonnie, Mustapha, Samai, Mohamed, Ishola, David, Lowe, Brett, Watson-Jones, Deborah and Greenwood, Brian (2022) 'Prevalence of malaria and helminth infections in rural communities in northern Sierra Leone, a baseline study to inform Ebola vaccine study protocols'. PLoS ONE, Vol 17, Issue 7, e0270968.
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2. Baiden ea 2022 - journal.pone.0270968.pdf - Published Version Available under License Creative Commons Attribution. Download (460kB) | Preview |
Abstract
Introduction
Recurrent parasitic infections may influence the immune response to vaccines. In the Partnership for Research on Ebola VACcinations extended follow-UP and clinical research capacity build-UP (PREVAC-UP) study being undertaken in Mambolo, northern Sierra Leone, participants are being followed up to assess the potential impact of exposure to malaria and/or helminth infections on long-term immune response to two Ebola vaccines. To support the development of the assays that will be used in this evaluation, a parasitological survey was conducted in Mambolo between November 2019 and February 2020.
Methods
Healthy individuals aged ≥1 year who were resident in Mambolo Chiefdom were selected using a stratified sampling approach and questionnaires were administered to explore their sociodemographic characteristics. Microscopy was used to detect malaria parasites, intestinal helminths and urinary schistosome infections. Rapid blood tests were used to detect infections with Onchocerca volvulus and Wuchereria bancrofti. We estimated the overall prevalence of these infections and used adjusted logistic regression models to explore risk factors for malaria and hookworm infection.
Results
Eight hundred and fifteen (815) residents, 50.9% of whom were female were surveyed. Overall, 309 (39.1%) of 791 persons tested for malaria had a positive blood slide; Plasmodium falciparum was the dominant species. Helminth infection was detected in 122 (15.0%) of 815 stool samples including three mixed infections. The helminth infections comprised 102 (12.5%) cases of hookworm, 11 (1.3%) cases of Trichuris trichiura, 10 (1.2%) cases of Schistosoma mansoni and two (0.2%) cases of Ascaris lumbricoides. Being male (OR = 2.01, 95% CI 1.15–3.50) and residing in a non-riverine community (OR = 4.02, 95%CI 2.32–6.98) were the factors associated with hookworm infection. Onchocerca volvulus and Wuchereria bancrofti infections were found in 3.3% and 0.4% of participants respectively.
Conclusion
Malaria and hookworm are the most prevalent parasite infections and those most likely to influence long-term immune response to Ebola vaccines among the trial participants.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NOT_LSTM |
| Subjects: | QW Microbiology and Immunology > Immunotherapy and Hypersensitivity > QW 806 Vaccination QX Parasitology > QX 45 Host-parasite relations WC Communicable Diseases > Tropical and Parasitic Diseases > WC 680 Tropical diseases (General) WC Communicable Diseases > Tropical and Parasitic Diseases > WC 695 Parasitic diseases (General) WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria |
| Faculty: Department: | Clinical Sciences & International Health > International Public Health Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1371/journal.pone.0270968 |
| Depositing User: | Rachel Dominguez |
| Date Deposited: | 19 Jun 2023 08:24 |
| Last Modified: | 19 Jun 2023 08:40 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/22647 |
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