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Evolutionary analysis of novel serine proteases in the venom gland transcriptome of Bitis gabonica rhinoceros.

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Vaiyapuri, Sakthivel, Wagstaff, Simon ORCID: https://orcid.org/0000-0003-0577-5537, Harrison, Robert, Gibbins, Jonathan M. and Hutchinson, E. Gail (2011) 'Evolutionary analysis of novel serine proteases in the venom gland transcriptome of Bitis gabonica rhinoceros.'. PLoS ONE, Vol 6, Issue 6, e21532.

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Official URL: http://www.plosone.org/article/info%3Adoi%2F10.137...

Abstract

Our study provides further insight into the diversity of serine protease isoforms present within snake venom and discusses their possible functions and how they may have evolved. These multiple serine protease isoforms with different substrate specificities may enhance the envenomation effects and help the snake to adapt to new habitats and diets. Our findings have potential for helping the future development of improved therapeutics for snake bites.

Item Type:	Article
Subjects:	WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Animal Poisons > WD 410 Reptiles
Faculty: Department:	Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI):	https://doi.org/10.1371/journal.pone.0021532
Depositing User:	Mary Creegan
Date Deposited:	24 Nov 2011 09:18
Last Modified:	17 Sep 2019 13:32
URI:	https://archive.lstmed.ac.uk/id/eprint/2439

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