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Antimalarial chemotherapy: young guns or back to the future?

Biagini, Giancarlo ORCID:, O'Neill, Paul M., Nzila, Alexis, Ward, Stephen ORCID: and Bray, Patrick (2003) 'Antimalarial chemotherapy: young guns or back to the future?'. Trends in Parasitology, Vol 19, Issue 11, pp. 479-487.

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The burgeoning global problem of malaria is largely due to the emergence of parasite resistance to our limited armamentarium of antimalarial drugs. The recognition of this impending disaster at the international level and the engagement of the pharmaceutical industry promise a more optimistic future for antimalarial drug development. This is particularly exciting when considering the advances in our understanding of parasite biology, which are currently being fuelled by the malaria genome project. This article discusses recent developments in the area of antimalarial drug discovery and evaluation. New advances, based on traditional antimalarial drug classes including the quinolines, peroxides and antifolates ('back to the future'), are discussed, followed by a presentation of some novel targets ('young guns') that have been shown to be good candidates for chemotherapeutic attack.

Item Type: Article
Subjects: QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 256 Antimalarials
QW Microbiology and Immunology > QW 45 Microbial drug resistance. General or not elsewhere classified.
WA Public Health > Preventive Medicine > WA 110 Prevention and control of communicable diseases. Transmission of infectious diseases
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 770 Therapy
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI):
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Depositing User: Ms Julia Martin
Date Deposited: 20 Jun 2012 03:25
Last Modified: 17 Jul 2020 10:57


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