A novel strain of Leishmania braziliensis harbors not a toti- but a bunyavirus

Kostygov, Alexei Yu., Grybchuk, Danyil, Heeren, Senne, Gerasimov, Evgeny S., Klocek, Donnamae, Reddy, Aditya, Sádlová, Jovana, Pacáková, Lenka, Kohl, Alain, Stejskal, František, Volf, Petr, Dujardin, Jean-Claude and Yurchenko, Vyacheslav (2024) 'A novel strain of Leishmania braziliensis harbors not a toti- but a bunyavirus'. PLoS Neglected Tropical Diseases, Vol 18, Issue 12, e0012767.

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Abstract

Leishmania is a genus of the family Trypanosomatidae that unites obligatory parasitic flagellates causing a variety of vector-borne diseases collectively called leishmaniasis. The symptoms range from relatively innocuous skin lesions to complete failures of visceral organs. The disease is exacerbated if a parasite harbors Leishmania RNA viruses (LRVs) of the family Pseudototiviridae. Screening a novel isolate of L. braziliensis, we revealed that it possesses not a toti-, but a bunyavirus of the family Leishbuviridae. To the best of our knowledge, this is a very first discovery of a bunyavirus infecting a representative of the Leishmania subgenus Viannia. We suggest that these viruses may serve as potential factors of virulence in American leishmaniasis and encourage researchers to test leishmanial strains for the presence of not only LRVs, but also other RNA viruses.

Item Type:	Article
Subjects:	QX Parasitology > QX 20 Research (General) WC Communicable Diseases > Tropical and Parasitic Diseases > WC 695 Parasitic diseases (General) WC Communicable Diseases > Tropical and Parasitic Diseases > WC 715 Visceral leishmaniasis
Faculty: Department:	Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI):	https://doi.org/10.1371/journal.pntd.0012767
SWORD Depositor:	JISC Pubrouter
Depositing User:	JISC Pubrouter
Date Deposited:	15 Jan 2025 10:17
Last Modified:	15 Jan 2025 10:17
URI:	https://archive.lstmed.ac.uk/id/eprint/25970

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