Pharmacokinetics of chloroquine in Indian tribal and non-tribal healthy volunteers and patients with Plasmodium falciparum malaria

Dua, V. K., Gupta, N. C., Kar, P. K., Edwards, Geoffrey, Singh, N. and Sharma, V. P. (2002) 'Pharmacokinetics of chloroquine in Indian tribal and non-tribal healthy volunteers and patients with Plasmodium falciparum malaria'. Current Science, Vol 83, Issue 9, pp. 1128-1131.

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Abstract

The pharmacokinetics of chloroquine was studied in Indian tribal and non-tribal healthy volunteers and patients infected with Plasmodium falciparum malaria, after a single dose of 600-mg chloroquine. Mean area under the curve (AUC), half-life (T-1/2) and peak concentration (C-max) in tribal P. falciparum patients were 18.79 +/- 5.82 mug h ml(-1), 115.94 +/- 57.71 h and 435 +/- 135.17 ng ml(-1) respectively, while in non-tribal P. falciparum patients they were 17.00 +/- 5.60 mug h ml(-1), 76.15 +/- 8.00 h and 454 +/- 193 ng ml(-1) respectively. Pharmacokinetic parameters did not appreciably differ between-tribal and non-tribal groups of subjects in healthy volunteers or in P. falciparum patients. However, the time to reach maximum concentration (T-max) was 8 h in tribal subjects and 4 h in non-tribal subjects. Mean ratio of AUC of chloroquine to desethylchloroquine in tribal P. falciparum patients was higher (4.26 +/- 1.34) than non-tribal subjects (3.41 +/- 0.66), suggesting reduced chloroquine metabolism in tribal subjects. However, the difference was statistically insignificant (t = 1.35, P < 0.5). Delayed T-max and impaired chloroquine metabolism may be associated with general health problems such as malnutrition, anaemia and parasitic infestations of the tribal population in India.

Item Type:	Article
Subjects:	QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 256 Antimalarials QV Pharmacology > QV 38 Drug action. QX Parasitology > Protozoa > QX 135 Plasmodia WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria WC Communicable Diseases > Tropical and Parasitic Diseases > WC 770 Therapy
Depositing User:	Martin Chapman
Date Deposited:	13 Jun 2013 10:56
Last Modified:	22 Nov 2024 11:51
URI:	https://archive.lstmed.ac.uk/id/eprint/2911

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