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Kaleebu, P., French, Neil, Mahe, C., Yirrell, D., Watera, C., Lyagoba, F., Nakiyingi, J., Rutebemberwa, A., Morgan, D., Weber, J., Gilks, C.F. and Whitworth, J. (2002) 'Effect of human immunodeficiency virus (HIV) type 1 envelope subtypes A and D on disease progression in a large cohort of HIV-1-positive persons in Uganda'. Journal of Infectious Disease, Vol 185, Issue 9, pp. 1244-1250.
Full text not available from this repository.Abstract
The effect of human immunodeficiency virus (HIV) type 1 envelope subtypes A and D on disease progression was investigated in 1045 adults in Uganda. At enrollment and every 6 months, a clinical history, examination, and laboratory investigations that included CD4 cell counts were done. HIV-1 envelope subtype was assessed mainly by peptide serology supplemented by heteroduplex mobility assay and DNA sequencing. A multivariate analysis of survival was performed to assess the prognostic value of HIV-1 subtype on death. A marginal general linear model also determined the effect of subtype on CD4 cell count during follow-up. Subtype D was associated with faster progression to death (relative risk, 1.29; 95% confidence interval, 1.07-1.56; P = .009) and with a lower CD4 cell count during follow-up (P = .001), compared with subtype A, after adjusting for CD4 cell count at enrollment. In Africa, envelope subtype D is associated with faster disease progression, compared with subtype A.
| Item Type: | Article |
|---|---|
| Subjects: | WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections |
| Digital Object Identifer (DOI): | https://doi.org/10.1086/340130 |
| Depositing User: | Martin Chapman |
| Date Deposited: | 28 Feb 2013 09:54 |
| Last Modified: | 21 Nov 2019 14:48 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/2946 |
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