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Bacterial endosymbionts of Onchocerca volvulus in the pathogenesis of posttreatment reactions

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Keiser, P. B., Reynolds, S. M., Awadzi, K., Ottesen, E. A., Taylor, Mark ORCID: https://orcid.org/0000-0003-3396-9275 and Nutman, T. B. (2002) 'Bacterial endosymbionts of Onchocerca volvulus in the pathogenesis of posttreatment reactions'. Journal of Infectious Disease, Vol 185, Issue 6, pp. 805-811.

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Official URL: http://jid.oxfordjournals.org/content/185/6/805

Abstract

Treatment of onchocerciasis with diethylcarbamazine (DEC) or ivermectin is associated with a posttreatment reaction characterized by fever, tachycardia, hypotension, lymphadenopathy, and pruritus. To investigate the role of the Wolbachia bacterial endosymbiont of Onchocerca volvulus in these reactions, serum samples collected before and after treatment with either anthelmintic were assessed for evidence of Wolbachia DNA. By use of real-time quantitative polymerase chain reaction, Wolbachia DNA was detected in both groups-with significantly higher levels in those who received DEC(P<.0001). In the ivermectin group, there was a significant correlation between levels of bacterial DNA and serum tumor necrosis factor-α (P=.013). Peak DNA levels correlated with reaction scores (P=.048). Significant correlations were also seen between Wolbachia DNA and the antibacterial peptides calprotectin (P=.021) and calgranulin B (P<.0001). These findings support a role for Wolbachia products in mediating the inflammatory responses seen following treatment of onchocerciasis and suggest new targets for modulating these reactions.

Item Type:	Article
Subjects:	QU Biochemistry > Genetics > QU 475 Genetic processes QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 253 Anthelmintics QX Parasitology > Helminths. Annelida > QX 203 Nematoda QX Parasitology > Helminths. Annelida > QX 301 Filarioidea WC Communicable Diseases > Tropical and Parasitic Diseases > WC 885 Onchocerciasis
Digital Object Identifer (DOI):	https://doi.org/10.1086/339344
Depositing User:	Lynn Roberts-Maloney
Date Deposited:	23 Oct 2013 10:48
Last Modified:	16 Sep 2019 09:01
URI:	https://archive.lstmed.ac.uk/id/eprint/2949

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