LSTM Home > LSTM Research > LSTM Online Archive

Is 'timing' important for cytokine polarization?

Rhodes, Shelley G. and Graham, Simon P. (2002) 'Is 'timing' important for cytokine polarization?'. Trends in Immunology, Vol 23, Issue 5, pp. 246-249.

Full text not available from this repository.


A comparison of the longitudinal cytokine responses of cattle to infection with intracellular Mycobacterium bovis and extracellular Onchocerca ochengi illustrates the development of reciprocal interferon-gamma and interleukin-4 responses, which result ultimately in an infection-induced type-1 or type-2 polarization, respectively. These kinetic studies of natural host-pathogen relationships show that the cytokine responses to infection fluctuate over time, resulting in periods of polarization and nonpolarization before the establishment of a chronic infection. Here, we discuss our data from cattle in the light of the current understanding of cytokine polarization towards infection in mouse models and humans.

Item Type: Article
Subjects: QW Microbiology and Immunology > Immunity by Type > QW 568 Cellular immunity. Immunologic cytotoxicity. Immunocompetence. Immunologic factors (General)
WC Communicable Diseases > Infection. Bacterial Infections > Other Bacterial Infections. Zoonotic Bacterial Infections > WC 302 Actinomycetales infections. Mycobacterium infections
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 885 Onchocerciasis
WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General)
Digital Object Identifer (DOI):
Depositing User: Lynn Roberts-Maloney
Date Deposited: 26 Jun 2013 12:22
Last Modified: 29 Nov 2018 12:23


View details

Actions (login required)

Edit Item Edit Item