B-lymphotropic viruses in a novel tropical splenic lymphoma

Bates, Imelda ORCID: https://orcid.org/0000-0002-0862-8199, Bedu-Addo, G., Jarrett, R. F., Schulz, T., Wallace, S., Armstrong, A., Sheldon, J. and Rutherford, T. (2001) 'B-lymphotropic viruses in a novel tropical splenic lymphoma'. British Journal of Haematology, Vol 112, Issue 1, pp. 161-166.

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Abstract

Peripheral blood from patients with a novel tropical splenic lymphoma, characterized by splenomegaly and circulating naive CD5-negative villous B lymphocytes, has been screened for evidence of an association with the B-lymphotropic viruses, Epstein-Barr virus (EBV), hepatitis C virus (HCV) and human herpesvirus 8 (HHV8). No increased prevalence of EBV, HCV and HHV8 was demonstrated using serological and molecular techniques, compared with a geographical, age-matched control group. However, lymphoma patients had markedly raised EBV antibody levels without a concomitant increase in the rate of detection of viral genomes in the peripheral blood. This phenomenon also occurred in patients with hyper-reactive malarial splenomegaly, a condition that occurs in the same geographical area and that is clinically indistinguishable from tropical splenic lymphoma, adding further weight to the suggestion that there may be an aetiological association between these two disorders.

Item Type:	Article
Subjects:	QW Microbiology and Immunology > Viruses > QW 160 Viruses (General). Virology WC Communicable Diseases > Virus Diseases > Infectious Viral Skin Diseases > WC 571 Herpesviridae infections WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria WH Hemic and Lymphatic Systems > Hematologic Diseases. Immunologic Factors. Blood Banks > WH 200 Leukocytes. Leukocyte disorders (General) WH Hemic and Lymphatic Systems > Lymphatic System > WH 600 Spleen
Faculty: Department:	Pre 2002
Digital Object Identifer (DOI):	https://doi.org/10.1046/j.1365-2141.2001.02517.x
Depositing User:	Lynn Roberts-Maloney
Date Deposited:	02 Oct 2013 10:40
Last Modified:	22 Oct 2019 08:22
URI:	https://archive.lstmed.ac.uk/id/eprint/3109

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