On the ancestral recruitment of metalloproteinases into the venom of snakes

Casewell, Nicholas ORCID: https://orcid.org/0000-0002-8035-4719 (2012) 'On the ancestral recruitment of metalloproteinases into the venom of snakes'. Toxicon, Vol 60, Issue 4, pp. 449-454.

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Abstract

Tracing the evolutionary history of proteins can reveal insights into gene alterations responsible for changes in structure and function. Here, the origin of snake venom metalloproteinases was rigorously reassessed using phylogenetics and the reconstruction of ancestral sequences. Basal SVMPs are most closely related to ADAM 7, 28 and decysin-1 proteins. Reconstructing the evolutionary history of these proteins and their hypothetical ancestors reveals progressive alterations in the amino acid composition and structural characteristics of ADAMs/SVMPs through evolutionary time.

Item Type:	Article
Subjects:	QU Biochemistry > Genetics > QU 470 Genetic structures QU Biochemistry > Proteins. Amino Acids. Peptides > QU 58.5 DNA. WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Animal Poisons > WD 410 Reptiles
Faculty: Department:	Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.toxicon.2012.02.006
Depositing User:	Lynn Roberts-Maloney
Date Deposited:	15 Dec 2014 10:28
Last Modified:	06 Feb 2018 13:08
URI:	https://archive.lstmed.ac.uk/id/eprint/4655

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