HIV-exposed uninfected children: a growing population with a vulnerable immune system?

Afran, L., Garcia Knight, M., Nduati, E., Urban, Britta ORCID: https://orcid.org/0000-0002-4197-8393, Heyderman, R. S. and Rowland-Jones, S. L. (2014) 'HIV-exposed uninfected children: a growing population with a vulnerable immune system?'. Clinical and Experimental Immunology, Vol 176, Issue 1, pp. 11-22.

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Abstract

Through the successful implementation of policies to prevent mother-to-child-transmission (PMTCT) of HIV-1 infection, children born to HIV-1-infected mothers are now much less likely to acquire HIV-1 infection than previously. Nevertheless, HIV-1-exposed uninfected (HEU) children have substantially increased morbidity and mortality compared with children born to uninfected mothers (unexposed uninfected, UU), predominantly from infectious causes. Moreover, a range of phenotypical and functional immunological differences between HEU and UU children has been reported. As the number of HEU children continues to increase worldwide, two questions with clear public health importance need to be addressed: first, does exposure to HIV-1 and/or ART in utero or during infancy have direct immunological consequences, or are these poor outcomes simply attributable to the obvious disadvantages of being born into an HIV-affected household? Secondly, can we expect improved maternal care and ART regimens during and after pregnancy, together with optimized infant immunization schedules, to reduce the excess morbidity and mortality of HEU children?

Item Type:	Article
Subjects:	QW Microbiology and Immunology > Reference Works. General Immunology > QW 520 Research (General) WA Public Health > Preventive Medicine > WA 110 Prevention and control of communicable diseases. Transmission of infectious diseases WA Public Health > WA 30 Socioeconomic factors in public health (General) WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections
Faculty: Department:	Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI):	https://doi.org/10.1111/cei.12251
Depositing User:	Lynn Roberts-Maloney
Date Deposited:	20 Apr 2015 13:53
Last Modified:	06 Feb 2018 13:09
URI:	https://archive.lstmed.ac.uk/id/eprint/5091

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