Developing retinal biomarkers of neurological disease: an analytical perspective

MacCormick, Ian JC, Czanner, Gabriela and Faragher, Brian (2015) 'Developing retinal biomarkers of neurological disease: an analytical perspective'. Biomarkers in Medicine, Vol 9, Issue 7, pp. 697-701.

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Abstract

The inaccessibility of the brain poses a problem for neuroscience. Scientists have traditionally responded by developing biomarkers for brain physiology and disease. The retina is an attractive source of biomarkers since it shares many features with the brain. Some even describe the retina as a ‘window’ to the brain, implying that retinal signs are analogous to brain disease features. However, new analytical methods are needed to show whether or not retinal signs really are equivalent to brain abnormalities, since this requires greater evidence than direct associations between retina and brain. We, therefore propose a new way to think about, and test, how clearly one might see the brain through the retinal window, using cerebral malaria as a case study.

Item Type:	Article
Subjects:	WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria WL Nervous System > WL 20 Research (General) WW Ophthalmology > WW 20 Research (General) WW Ophthalmology > Eye Structures and their Diseases > WW 270 Retina
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.2217/bmm.15.17
Depositing User:	Jessica Jones
Date Deposited:	11 Feb 2016 16:35
Last Modified:	06 Feb 2018 13:11
URI:	https://archive.lstmed.ac.uk/id/eprint/5520

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