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Osman, R K, Mortimer, Kevin 
ORCID: https://orcid.org/0000-0002-8118-8871, Bjune, G and El Sony, A I
(2016)
'Chronic respiratory disease in adults treated for tuberculosis in Khartoum, Sudan'. Public health action, Vol 6, Issue 3, 199-204(6).
Abstract
Background:
Chronic respiratory disease (CRD) causes substantial morbidity and mortality. Although the global CRD epidemic collides with the tuberculosis (TB) epidemic in many low- and middle-income country settings, the risk of TB-associated CRD is not well described in countries with a high burden of TB.
Methods:
We recruited 136 patients with a history of sputum smear-positive pulmonary TB (PTB) from the TB clinic at Omdurman Teaching Hospital in Khartoum, Sudan, and 136 age- and sex-matched community controls, between 28 July 2013 and 30 December 2013. Data were collected using standardised questionnaires and spirometry was performed before and after bronchodilator.
Results:
The mean age of the subjects with previous PTB and controls was respectively 44.0 years (SD 8.5) and 44.5 years (SD 8.6), with 27.2% females in both groups. Chronic respiratory symptoms such as chronic cough (OR 6.67, 95%CI 2.98–14.90, P < 0.001) and the presence of chronic airflow obstruction (OR 12.4, 95%CI 1.56–98.40, P = 0.02) were both strongly associated with a past history of PTB after adjusting for potential confounders.
Conclusion:
The clinical features of CRDs are strongly associated with past history of PTB. An integrated approach to improve the management of these common conditions should be considered.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COPD; airflow obstruction; low- and middle-income countries; pulmonary tuberculosis; spirometry |
| Subjects: | WA Public Health > WA 30 Socioeconomic factors in public health (General) WF Respiratory System > WF 140 Diseases of the respiratory system (General) WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General) |
| Faculty: Department: | Clinical Sciences & International Health > Clinical Sciences Department |
| Digital Object Identifer (DOI): | https://doi.org/10.5588/pha.16.0030 |
| SWORD Depositor: | JISC Pubrouter |
| Depositing User: | JISC Pubrouter |
| Date Deposited: | 20 Oct 2016 12:27 |
| Last Modified: | 12 Sep 2019 13:07 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/6266 |
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