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Maternal Malaria and Malnutrition (M3) Initiative, a pooled birth cohort of 13 pregnancy studies in Africa and the Western Pacific

Unger, Holger W, Cates, Jordan E, Gutman, Julie, Briand, Valerie, Fievet, Nadine, Valea, Innocent, Tinto, Halidou, d'Alessandro, Umberto, Landis, Sarah H, Adu-Afarwuah, Seth, Dewey, Kathryn G, terKuile, Feiko ORCID:, Dellicour, Stephanie, Ouma, Peter, Slutsker, Laurence, Terlouw, Anja ORCID:, Kariuki, Simon, Ayisi, John, Nahlen, Bernard, Desai, Meghna, Madanitsa, Mwayi, Kalilani-Phir, Linda, Ashorn, Per, Maleta, Kenneth, Mueller, Ivo, Stanisic, Danielle, Schmiegelow, Christentze, Lusingu, John, Westreich, Daniel, vanEijk, Anna ORCID:, Meshnick, Steven and Rogerson, Stephen (2016) 'Maternal Malaria and Malnutrition (M3) Initiative, a pooled birth cohort of 13 pregnancy studies in Africa and the Western Pacific'. British Medical Journal (BMJ), Vol 6, Issue 12, e012697.

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The Maternal Malaria and Malnutrition (M3) initiative has pooled together 13 studies with the hope of improving understanding of malaria–nutrition interactions during pregnancy and to foster collaboration between nutritionists and malariologists.

Data were pooled on 14 635 singleton, live birth pregnancies from women who had participated in 1 of 13 pregnancy studies. The 13 studies cover 8 countries in Africa and Papua New Guinea in the Western Pacific conducted from 1996 to 2015.

Findings to date
Data are available at the time of antenatal enrolment of women into their respective parent study and at delivery. The data set comprises essential data such as malaria infection status, anthropometric assessments of maternal nutritional status, presence of anaemia and birth weight, as well as additional variables such gestational age at delivery for a subset of women. Participating studies are described in detail with regard to setting and primary outcome measures, and summarised data are available from each contributing cohort.

Future plans
This pooled birth cohort is the largest pregnancy data set to date to permit a more definite evaluation of the impact of plausible interactions between poor nutritional status and malaria infection in pregnant women on fetal growth and gestational length. Given the current comparative lack of large pregnancy cohorts in malaria-endemic settings, compilation of suitable pregnancy cohorts is likely to provide adequate statistical power to assess malaria–nutrition interactions, and could point towards settings where such interactions are most relevant. The M3 cohort may thus help to identify pregnant women at high risk of adverse outcomes who may benefit from tailored intensive antenatal care including nutritional supplements and alternative or intensified malaria prevention regimens, and the settings in which these interventions would be most effective.

Item Type: Article
Subjects: WA Public Health > Health Problems of Special Population Groups > WA 310 Maternal welfare
WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Nutrition Disorders > WD 105 Deficiency diseases
WQ Obstetrics > Childbirth. Prenatal Care > WQ 175 Prenatal care
WQ Obstetrics > Pregnancy Complications > WQ 240 Pregnancy complications (General)
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):
Depositing User: Helen Wong
Date Deposited: 23 Nov 2016 11:51
Last Modified: 13 Sep 2019 13:10


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