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Characterization of a transferable plasmid-borne mcr-1 in a colistin resistant Shigella flexneri isolate.

Liang, Beibei, Roberts, Adam ORCID:, Xu, Xuebin, Yang, Chaojie, Yang, Xiaoxia, Wang, Jinyan, Yi, Shengjie, Li, Yongrui, Ma, Qiuxia, Wu, Fuli, Qiu, Shaofu and Song, Hongbin (2018) 'Characterization of a transferable plasmid-borne mcr-1 in a colistin resistant Shigella flexneri isolate.'. Applied and environmental microbiology, Vol 84, Issue 8, e02655-17.

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Since its initial discovery in an isolate from China, has also been detected in and , and is rarely reported in other Enterobacteriaceae. Here, we report the isolation and identification of a strain harboring from stool samples in a pig farm in China from 2009. The minimum inhibitory concentration (MIC) to colistin of the isolate is 4 μg/mL. Conjugation assays showed the donor strain has functional and transferable colistin resistance. Sequencing revealed that was present on a putative composite transposon flanked by inverted repeats of IS There are four species of , is the most frequently isolated species in Low and Middle Income Countries (LMICs). In this study, we report a functional, transferable, plasmid mediated in We have shown is located on a novel composite transposon which is flanked by inverted repeats of IS The host strain is multi-drug resistant and this multidrug resistance is also transferable. The finding of functional in ; a human associated Enterobacteriaceae is a cause for concern as infections due to are the main infections in most Low and Middle Income Countries. [Abstract copyright: Copyright © 2018 Liang et al.]

Item Type: Article
Subjects: QW Microbiology and Immunology > Bacteria > QW 138 Enterobacteriaceae
QW Microbiology and Immunology > QW 45 Microbial drug resistance. General or not elsewhere classified.
WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):
SWORD Depositor: JISC Pubrouter
Depositing User: Stacy Murtagh
Date Deposited: 14 Mar 2018 17:06
Last Modified: 06 Sep 2019 09:34


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