%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Benjamin F. R. Dickson, Patricia M. Graves, Ni Ni Aye, Thet Wai Nwe, Tint Wai, San San Win, Myint Shwe, Janet Douglass, Richard S. Bradbury, William J. McBride
The prevalence of lymphatic filariasis infection and disease following six rounds of mass drug administration in Mandalay Region, Myanmar
www.plosntds.org
www.plosntds.org
endstream
endobj
3 0 obj
<>
endobj
4 0 obj
<>/XObject<>>>
endobj
6 0 obj
[18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R 49 0 R]
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref001)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref001)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref002)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref003)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref004)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref005)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref006)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref004)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref005)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref007)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref003)>>
endobj
29 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref005)>>
endobj
30 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref005)>>
endobj
31 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref006)>>
endobj
32 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref005)>>
endobj
33 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref006)>>
endobj
34 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref005)>>
endobj
35 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref007)>>
endobj
36 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref003)>>
endobj
37 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref005)>>
endobj
38 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref007)>>
endobj
39 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref008)>>
endobj
40 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref004)>>
endobj
41 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref005)>>
endobj
42 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref005)>>
endobj
43 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref007)>>
endobj
44 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref005)>>
endobj
45 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref007)>>
endobj
46 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref004)>>
endobj
47 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref005)>>
endobj
48 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref007)>>
endobj
49 0 obj
<>/Border[0 0 0]/A 50 0 R>>
endobj
50 0 obj
<>
endobj
7 0 obj
<>stream
q
Q
q
12.0189 54.5953 583.087 707.414 re
W* n
q
1 0 0 1 12.0189 54.5953 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
0.955 g
0.0001 w
200 714 m
576 714 l
576 546 l
200 546 l
f*
0.83 0.64 0.02 0 k
273.543 458.929 m
278.306 458.929 l
h
f*
468.227 406.942 m
472.989 406.942 l
h
f*
477.411 406.942 m
482.173 406.942 l
h
f*
392.655 393.902 m
397.417 393.902 l
h
f*
401.896 393.902 m
406.658 393.902 l
h
f*
240.378 328.932 m
245.14 328.932 l
h
f*
249.562 328.932 m
254.324 328.932 l
h
f*
426.784 315.95 m
431.546 315.95 l
h
f*
436.025 315.95 m
440.787 315.95 l
h
f*
445.209 315.95 m
449.972 315.95 l
h
f*
560.069 289.928 m
564.775 289.928 l
h
f*
200.013 276.945 m
204.775 276.945 l
h
f*
209.197 276.945 m
213.959 276.945 l
h
f*
277.965 263.906 m
282.671 263.906 l
h
f*
287.15 263.906 m
291.912 263.906 l
h
f*
230.457 237.94 m
235.219 237.94 l
h
f*
240.378 237.94 m
245.14 237.94 l
h
f*
475.37 224.901 m
480.132 224.901 l
h
f*
484.611 224.901 m
489.373 224.901 l
h
f*
493.795 224.901 m
498.557 224.901 l
h
f*
503.036 224.901 m
507.798 224.901 l
h
f*
567.666 198.935 m
572.428 198.935 l
h
f*
200.013 185.896 m
204.775 185.896 l
h
f*
224.674 172.913 m
229.436 172.913 l
h
f*
305.631 146.948 m
310.394 146.948 l
h
f*
314.872 146.948 m
319.578 146.948 l
h
f*
488.523 107.943 m
493.285 107.943 l
h
f*
497.764 107.943 m
502.526 107.943 l
h
f*
506.948 107.943 m
511.71 107.943 l
h
f*
0 g
1 j
1 J
10 0 0 10 209.99 696.983 cm
BT
/F5 1 Tf
-0.004 Tc
1 TL
0 0 Td
(this)Tj
1.6724 0 Td
(swelling)Tj
3.4639 0 Td
(results)Tj
2.8119 0 Td
(in)Tj
1.0319 0 Td
(significant)Tj
4.388 0 Td
(disfigurement)Tj
5.8109 0 Td
(and)Tj
1.7292 0 Td
(disability)Tj
3.8494 0 Td
(for)Tj
1.389 0 Td
(sufferers.)Tj
3.8607 0 Td
(In)Tj
1.1055 0 Td
(2000,)Tj
-31.1128 -1.2982 Td
(Myanmar)Tj
4.1782 0 Td
(commenced)Tj
5.1363 0 Td
(a)Tj
0.652 0 Td
(National)Tj
3.6907 0 Td
(Program)Tj
3.7474 0 Td
(to)Tj
1.0261 0 Td
(Eliminate)Tj
4.0932 0 Td
(LF)Tj
1.2869 0 Td
(through)Tj
3.4469 0 Td
(the)Tj
1.4684 0 Td
(annual)Tj
2.9593 0 Td
(mass)Tj
2.194 0 Td
(drug)Tj
-33.8794 -1.2983 Td
(administration)Tj
6.1681 0 Td
(\(MDA\))Tj
3.2145 0 Td
(of)Tj
1.0148 0 Td
(two)Tj
1.7121 0 Td
(de-worming)Tj
5.1817 0 Td
(medications:)Tj
5.3234 0 Td
(albendazole)Tj
4.9323 0 Td
(and)Tj
1.7291 0 Td
(diethylcarbama-)Tj
-29.276 -1.3039 Td
(zine)Tj
1.8708 0 Td
(to)Tj
1.0261 0 Td
(all)Tj
1.1452 0 Td
(endemic)Tj
3.6567 0 Td
(districts.)Tj
3.6227 0 Td
(However)Tj
3.8494 0 Td
(there)Tj
2.262 0 Td
(remains)Tj
3.4469 0 Td
(little)Tj
2.0013 0 Td
(reliable)Tj
3.1351 0 Td
(information)Tj
5.0796 0 Td
(on)Tj
1.2756 0 Td
(how)Tj
-32.3714 -1.2983 Td
(well)Tj
1.8198 0 Td
(the)Tj
1.4683 0 Td
(elimination)Tj
4.8472 0 Td
(program)Tj
3.7077 0 Td
(is)Tj
0.8504 0 Td
(working,)Tj
3.7814 0 Td
(and)Tj
1.7348 0 Td
(how)Tj
1.9332 0 Td
(large)Tj
2.1657 0 Td
(the)Tj
1.4683 0 Td
(burden)Tj
3.1238 0 Td
(of)Tj
1.0148 0 Td
(disease)Tj
3.016 0 Td
(is)Tj
0.8504 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
-32.8193 -1.2982 Td
(country.)Tj
3.5773 0 Td
(This)Tj
1.9899 0 Td
(study)Tj
2.3867 0 Td
(assessed)Tj
3.4753 0 Td
(the)Tj
1.4683 0 Td
(prevalence)Tj
4.4844 0 Td
(of)Tj
1.0148 0 Td
(LF)Tj
1.2869 0 Td
(and)Tj
1.7291 0 Td
(participation)Tj
5.3688 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(MDA)Tj
2.5342 0 Td
(program)Tj
-31.8215 -1.3039 Td
(in)Tj
1.0374 0 Td
(24)Tj
1.1679 0 Td
(villages)Tj
3.1181 0 Td
(across)Tj
2.6815 0 Td
(four)Tj
1.9106 0 Td
(townships)Tj
4.2916 0 Td
(of)Tj
1.0148 0 Td
(Mandalay)Tj
4.1953 0 Td
(Region)Tj
3.05 0 Td
(in)Tj
1.0375 0 Td
(central)Tj
2.965 0 Td
(Myanmar.)Tj
4.3993 0 Td
(The)Tj
1.7859 0 Td
(study)Tj
-32.6549 -1.2983 Td
(found)Tj
2.6191 0 Td
(ongoing)Tj
3.532 0 Td
(filarial)Tj
2.7723 0 Td
(infection)Tj
3.7927 0 Td
(suggesting)Tj
4.3993 0 Td
(that)Tj
1.7802 0 Td
(the)Tj
1.4683 0 Td
(six)Tj
1.3153 0 Td
(rounds)Tj
3.0614 0 Td
(of)Tj
1.0148 0 Td
(MDA)Tj
2.5341 0 Td
(had)Tj
1.7065 0 Td
(not)Tj
1.576 0 Td
(been)Tj
2.1203 0 Td
(suffi-)Tj
-33.6923 -1.2983 Td
(cient)Tj
2.1826 0 Td
(to)Tj
1.0261 0 Td
(stop)Tj
1.8992 0 Td
(LF)Tj
1.287 0 Td
(transmission)Tj
5.3688 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4683 0 Td
(area.)Tj
2.109 0 Td
(It)Tj
0.8617 0 Td
(also)Tj
1.7688 0 Td
(identified)Tj
4.0535 0 Td
(a)Tj
0.6576 0 Td
(substantial)Tj
4.5014 0 Td
(burden)Tj
3.1238 0 Td
(of)Tj
1.0148 0 Td
(hydro-)Tj
-32.3544 -1.2982 Td
(coele)Tj
2.245 0 Td
(but)Tj
1.5534 0 Td
(no)Tj
1.2755 0 Td
(cases)Tj
2.2224 0 Td
(of)Tj
1.0148 0 Td
(lymphoedema.)Tj
6.1455 0 Td
(These)Tj
2.5681 0 Td
(results)Tj
2.8063 0 Td
(suggest)Tj
3.1238 0 Td
(that)Tj
1.7801 0 Td
(further)Tj
3.0274 0 Td
(rounds)Tj
3.0614 0 Td
(of)Tj
1.0148 0 Td
(effective)Tj
-31.8385 -1.304 Td
(MDA)Tj
2.5341 0 Td
(are)Tj
1.4513 0 Td
(required)Tj
3.634 0 Td
(to)Tj
1.0262 0 Td
(halt)Tj
1.7291 0 Td
(LF)Tj
1.2869 0 Td
(transmission)Tj
5.3631 0 Td
(and)Tj
1.7291 0 Td
(highlight)Tj
3.8155 0 Td
(the)Tj
1.4683 0 Td
(urgent)Tj
2.8516 0 Td
(need)Tj
2.143 0 Td
(for)Tj
1.389 0 Td
(morbidity)Tj
-30.4212 -1.2982 Td
(management)Tj
5.4368 0 Td
(programs)Tj
4.0648 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(country.)Tj
ET
Q
q
1 j
1 J
0.0001 w
11.9999 0 0 11.9999 200.012 489.997 cm
BT
/F2 1 Tf
-0.0033 Tc
1 TL
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0.0001 w
10 0 0 10 200.012 472.989 cm
BT
/F5 1 Tf
-0.004 Tc
1 TL
0 0 Td
(Lymphatic)Tj
4.5013 0 Td
(filariasis)Tj
3.515 0 Td
(\(LF\))Tj
1.9672 0 Td
(remains)Tj
3.4412 0 Td
(a)Tj
0.6577 0 Td
(major)Tj
2.6078 0 Td
(cause)Tj
2.3868 0 Td
(of)Tj
1.0148 0 Td
(permanent)Tj
4.6091 0 Td
(disability)Tj
3.8494 0 Td
(in)Tj
1.0318 0 Td
(tropical)Tj
3.2882 0 Td
(and)Tj
1.7291 0 Td
(sub-)Tj
-34.5994 -1.2982 Td
(tropical)Tj
3.2824 0 Td
(countries[)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(].)Tj
5.3291 0 Td
(Chronic)Tj
3.532 0 Td
(infection)Tj
3.7871 0 Td
(with)Tj
2.0012 0 Td
(mosquito-transmitted)Tj
9.0085 0 Td
(filarial)Tj
2.7779 0 Td
(worms)Tj
2.9593 0 Td
(leads)Tj
2.2167 0 Td
(to)Tj
-34.8942 -1.2983 Td
(lymphatic)Tj
4.2065 0 Td
(dysfunction,)Tj
5.1987 0 Td
(resulting)Tj
3.7304 0 Td
(in)Tj
1.0318 0 Td
(progressive,)Tj
4.972 0 Td
(irreversible)Tj
4.7054 0 Td
(swelling)Tj
3.464 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(limbs,)Tj
2.6475 0 Td
(breasts)Tj
2.9764 0 Td
(or)Tj
-35.4158 -1.3039 Td
(genitals.)Tj
3.4865 0 Td
(This)Tj
1.99 0 Td
(disfigurement)Tj
5.8053 0 Td
(causes)Tj
2.7496 0 Td
(significant)Tj
4.3936 0 Td
(pain,)Tj
2.211 0 Td
(disability,)Tj
4.0762 0 Td
(social)Tj
2.4548 0 Td
(stigma)Tj
2.8687 0 Td
(and)Tj
1.7291 0 Td
(economic)Tj
-31.7648 -1.2983 Td
(sequelae)Tj
3.5659 0 Td
(for)Tj
1.3833 0 Td
(sufferers.)Tj
3.8608 0 Td
(Worldwide,)Tj
4.9662 0 Td
(the)Tj
1.4684 0 Td
(South-East)Tj
4.5694 0 Td
(Asian)Tj
2.5171 0 Td
(Region)Tj
3.0558 0 Td
(has)Tj
1.542 0 Td
(the)Tj
1.4684 0 Td
(highest)Tj
3.0897 0 Td
(burden)Tj
3.1238 0 Td
(of)Tj
1.0148 0 Td
(LF,)Tj
-35.6256 -1.2982 Td
(accounting)Tj
4.6601 0 Td
(for)Tj
1.3889 0 Td
(half)Tj
1.7178 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(lost)Tj
1.6327 0 Td
(disability-adjusted)Tj
7.5571 0 Td
(life)Tj
1.4457 0 Td
(years)Tj
2.262 0 Td
(globally.[)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
4.5921 0 Td
(2)Tj
0 g
(])Tj
1.0375 0 Td
(Within)Tj
3.0954 0 Td
(the)Tj
1.4683 0 Td
(region,)Tj
-33.3408 -1.3039 Td
(Myanmar)Tj
4.1725 0 Td
(is)Tj
0.8504 0 Td
(one)Tj
1.6951 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(worst)Tj
2.4378 0 Td
(affected)Tj
3.3279 0 Td
(countries.[)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
5.2157 0 Td
(4)Tj
0 g
(])Tj
-18.992 -1.2983 Td
(In)Tj
1.1111 0 Td
(response,)Tj
3.9572 0 Td
(Myanmar)Tj
4.1782 0 Td
(established)Tj
4.5921 0 Td
(a)Tj
0.6576 0 Td
(National)Tj
3.6907 0 Td
(Program)Tj
3.7474 0 Td
(to)Tj
1.0261 0 Td
(Eliminate)Tj
4.0933 0 Td
(LF)Tj
1.2869 0 Td
(\(NPELF\))Tj
3.8267 0 Td
(in)Tj
1.0375 0 Td
(2000)Tj
2.126 0 Td
(as)Tj
-36.527 -1.2983 Td
(part)Tj
1.8425 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(World)Tj
2.8346 0 Td
(Health)Tj
2.9197 0 Td
(Organization's)Tj
6.0944 0 Td
(\(WHO\))Tj
3.3846 0 Td
(broader)Tj
3.3562 0 Td
(Global)Tj
2.88 0 Td
(Program)Tj
3.7473 0 Td
(to)Tj
1.0262 0 Td
(Eliminate)Tj
4.0932 0 Td
(LF.)Tj
-34.6618 -1.3039 Td
(The)Tj
1.7801 0 Td
(NPELF)Tj
3.1521 0 Td
(drew)Tj
2.228 0 Td
(upon)Tj
2.3187 0 Td
(historical)Tj
3.9232 0 Td
(reports,)Tj
3.2938 0 Td
(national)Tj
3.5036 0 Td
(data)Tj
1.9162 0 Td
(and)Tj
1.7291 0 Td
(a)Tj
0.652 0 Td
(1997)Tj
2.126 0 Td
(WHO)Tj
2.6985 0 Td
(multi-country)Tj
5.8621 0 Td
(prev-)Tj
-35.1834 -1.2983 Td
(alence)Tj
2.7155 0 Td
(mapping)Tj
3.7928 0 Td
(survey)Tj
2.8119 0 Td
(to)Tj
1.0261 0 Td
(define)Tj
2.6986 0 Td
(endemic)Tj
3.651 0 Td
(districts)Tj
3.3959 0 Td
(\(the)Tj
1.8085 0 Td
(implementation)Tj
6.6387 0 Td
(unit)Tj
1.8652 0 Td
(\(IU\))Tj
1.9729 0 Td
(used)Tj
2.0636 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
-35.4725 -1.2982 Td
(country\).[)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
4.9549 0 Td
(6)Tj
0 g
(])Tj
1.0375 0 Td
(Forty-five)Tj
4.1612 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(65)Tj
1.1736 0 Td
(districts)Tj
3.3958 0 Td
(in)Tj
1.0375 0 Td
(Myanmar)Tj
4.1726 0 Td
(were)Tj
2.1203 0 Td
(classified)Tj
3.8211 0 Td
(as)Tj
1.0148 0 Td
(LF-endemic,)Tj
5.295 0 Td
(with)Tj
-34.6674 -1.2983 Td
(47)Tj
1.1678 0 Td
(million)Tj
3.1238 0 Td
(people)Tj
2.8573 0 Td
(at-risk)Tj
2.7949 0 Td
(\(85.5%)Tj
2.9707 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(total)Tj
2.007 0 Td
(population\).[)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
6.1965 0 Td
(5)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
0.9184 0 Td
(7)Tj
0 g
(])Tj
1.0375 0 Td
(Baseline,)Tj
3.7303 0 Td
(pre)Tj
2.0466 0 Td
(mass)Tj
2.194 0 Td
(drug)Tj
-33.5279 -1.3039 Td
(administration)Tj
6.1681 0 Td
(\(MDA\),)Tj
3.4412 0 Td
(surveys)Tj
3.1692 0 Td
(indicated)Tj
3.9401 0 Td
(high)Tj
2.0069 0 Td
(levels)Tj
2.3754 0 Td
(of)Tj
1.0148 0 Td
(antigenaemia)Tj
5.5842 0 Td
(\(2030%\))Tj
4.0762 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(central)Tj
-34.2819 -1.2983 Td
(and)Tj
1.7291 0 Td
(western)Tj
3.3278 0 Td
(dry)Tj
1.5761 0 Td
(zones,)Tj
2.6985 0 Td
(consistent)Tj
4.2577 0 Td
(with)Tj
1.9955 0 Td
(that)Tj
1.7802 0 Td
(seen)Tj
1.9786 0 Td
(in)Tj
1.0318 0 Td
(Myanmar)Tj
4.1782 0 Td
(migrants)Tj
3.7814 0 Td
(living)Tj
2.4718 0 Td
(in)Tj
1.0318 0 Td
(Thailand.[)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
-31.8385 -1.2982 Td
(5)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
0.9184 0 Td
(6)Tj
0 g
(])Tj
1.0374 0 Td
(Meanwhile,)Tj
4.8926 0 Td
(the)Tj
1.4683 0 Td
(northern,)Tj
4.0422 0 Td
(eastern)Tj
3.0784 0 Td
(and)Tj
1.7348 0 Td
(southern)Tj
3.7814 0 Td
(areas)Tj
2.245 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(country)Tj
3.3505 0 Td
(were)Tj
2.126 0 Td
(less)Tj
1.61 0 Td
(endemic)Tj
3.6567 0 Td
(or)Tj
-36.4249 -1.3039 Td
(free)Tj
1.7234 0 Td
(from)Tj
2.2053 0 Td
(filariasis.[)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
4.7849 0 Td
(6)Tj
0 g
(])Tj
1.0375 0 Td
(In)Tj
1.1055 0 Td
(Mandalay)Tj
4.1952 0 Td
(Region,)Tj
3.2769 0 Td
(the)Tj
1.4683 0 Td
(site)Tj
1.5704 0 Td
(of)Tj
1.0148 0 Td
(this)Tj
1.6724 0 Td
(study,)Tj
2.6192 0 Td
(the)Tj
1.4683 0 Td
(baseline)Tj
3.4299 0 Td
(prevalence)Tj
4.4844 0 Td
(by)Tj
-36.0564 -1.2983 Td
(microfilaraemia)Tj
6.5933 0 Td
(\(mf\))Tj
2.0069 0 Td
(was)Tj
1.7008 0 Td
(5.2%)Tj
2.1486 0 Td
(\(range:)Tj
3.0331 0 Td
(0.2)Tj
1.3946 0 Td
(to)Tj
1.0262 0 Td
(14.7%\))Tj
2.9706 0 Td
(and)Tj
1.7292 0 Td
(by)Tj
1.1792 0 Td
(antigenaemia)Tj
5.5842 0 Td
(ranged)Tj
2.9934 0 Td
(from)Tj
2.2053 0 Td
(2)Tj
0.6917 0 Td
(to)Tj
/F10 1 Tf
0 Tc
-35.2571 -1.2983 Td
(>)Tj
/F5 1 Tf
-0.004 Tc
(25%.[)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(])Tj
5.0739 0 Td
(The)Tj
1.7802 0 Td
(parasite)Tj
/F11 1 Tf
3.3278 0 Td
()Tj
4.8472 0 Td
( \n\r)Tj
/F5 1 Tf
3.7644 0 Td
(is)Tj
0.8448 0 Td
(the)Tj
1.474 0 Td
(sole)Tj
1.7574 0 Td
(documented)Tj
5.2441 0 Td
(cause)Tj
2.3924 0 Td
(of)Tj
1.0148 0 Td
(LF)Tj
1.2869 0 Td
(in)Tj
1.0318 0 Td
(Myan-)Tj
-33.8397 -1.3039 Td
(mar,)Tj
2.0692 0 Td
(where)Tj
2.6476 0 Td
(it)Tj
0.788 0 Td
(is)Tj
0.8504 0 Td
(transmitted)Tj
4.8642 0 Td
(by)Tj
1.1849 0 Td
(the)Tj
1.4683 0 Td
(mosquito)Tj
/F11 1 Tf
4.0139 0 Td
()Tj
2.4888 0 Td
(\n\r)Tj
/F5 1 Tf
(.[)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
8.0843 0 Td
(5)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
0.9184 0 Td
(7)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
0.9241 0 Td
(8)Tj
0 g
(])Tj
-29.1059 -1.2983 Td
(Under)Tj
2.8289 0 Td
(the)Tj
1.4684 0 Td
(first)Tj
1.8085 0 Td
(component)Tj
4.8131 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(Global)Tj
2.8743 0 Td
(Program)Tj
3.7474 0 Td
(to)Tj
1.0261 0 Td
(Eliminate)Tj
4.0932 0 Td
(LF,)Tj
1.5137 0 Td
(Myanmar)Tj
4.1726 0 Td
(began)Tj
2.6022 0 Td
(con-)Tj
-34.6278 -1.2982 Td
(ducting)Tj
3.2768 0 Td
(annual,)Tj
3.1861 0 Td
(single-dose)Tj
4.6998 0 Td
(MDA)Tj
2.5342 0 Td
(with)Tj
1.9955 0 Td
(albendazole)Tj
4.9323 0 Td
(and)Tj
1.7291 0 Td
(diethylcarbamazine)Tj
8.039 0 Td
(\(DEC\))Tj
2.8687 0 Td
(in)Tj
1.0374 0 Td
(2001.[)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
-34.2989 -1.3039 Td
(5)Tj
0 g
(])Tj
1.0318 0 Td
(Since)Tj
2.3584 0 Td
(then,)Tj
2.245 0 Td
(the)Tj
1.4683 0 Td
(coverage)Tj
3.7247 0 Td
(has)Tj
1.5421 0 Td
(been)Tj
2.1259 0 Td
(progressively)Tj
5.4425 0 Td
(expanded,)Tj
4.3143 0 Td
(reaching)Tj
3.6794 0 Td
(all)Tj
1.1452 0 Td
(endemic)Tj
3.651 0 Td
(districts)Tj
3.3958 0 Td
(by)Tj
-36.1244 -1.2983 Td
(2015.[)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(])Tj
3.5035 0 Td
(With)Tj
2.2791 0 Td
(the)Tj
1.4683 0 Td
(exception)Tj
4.0932 0 Td
(of)Tj
1.0148 0 Td
(six)Tj
1.3153 0 Td
(districts)Tj
3.3959 0 Td
(\(three)Tj
2.6022 0 Td
(in)Tj
1.0374 0 Td
(Sagaing)Tj
3.3109 0 Td
(Region,)Tj
3.2768 0 Td
(two)Tj
1.7065 0 Td
(in)Tj
1.0374 0 Td
(Mandalay)Tj
4.1896 0 Td
(Region)Tj
-34.2309 -1.2983 Td
(and)Tj
1.7291 0 Td
(one)Tj
1.7007 0 Td
(in)Tj
1.0319 0 Td
(Magway)Tj
3.5886 0 Td
(Region\))Tj
3.3902 0 Td
(that)Tj
1.7802 0 Td
(have)Tj
2.0579 0 Td
(passed)Tj
2.846 0 Td
(Transmission)Tj
5.6749 0 Td
(Assessment)Tj
4.8642 0 Td
(Surveys)Tj
3.2882 0 Td
(\(TAS\),)Tj
2.897 0 Td
(all)Tj
1.1452 0 Td
(are)Tj
-35.9941 -1.2982 Td
(continuing)Tj
4.6204 0 Td
(MDA)Tj
2.5342 0 Td
(rounds.[)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
4.3313 0 Td
(7)Tj
0 g
(])Tj
1.0318 0 Td
(Whilst)Tj
2.8856 0 Td
(the)Tj
1.474 0 Td
(WHO)Tj
2.6986 0 Td
(recommends)Tj
5.4425 0 Td
(annual)Tj
2.9593 0 Td
(MDA)Tj
2.5342 0 Td
(rounds)Tj
3.0614 0 Td
(for)Tj
1.3889 0 Td
(at)Tj
-34.9622 -1.304 Td
(least)Tj
1.9842 0 Td
(five)Tj
1.6497 0 Td
(consecutive)Tj
4.8813 0 Td
(years,)Tj
2.4888 0 Td
(several)Tj
2.931 0 Td
(challenges)Tj
4.32 0 Td
(resulted)Tj
3.4015 0 Td
(in)Tj
1.0375 0 Td
(two)Tj
1.7064 0 Td
(to)Tj
1.0262 0 Td
(three)Tj
2.262 0 Td
(year)Tj
1.9049 0 Td
(intervals)Tj
3.6283 0 Td
(between)Tj
-33.2218 -1.2982 Td
(rounds.)Tj
3.2881 0 Td
(At)Tj
1.2019 0 Td
(the)Tj
1.4683 0 Td
(national)Tj
3.5036 0 Td
(level,)Tj
2.2394 0 Td
(problems)Tj
3.9741 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4684 0 Td
(supply)Tj
2.8459 0 Td
(of)Tj
1.0148 0 Td
(DEC)Tj
2.1883 0 Td
(precluded)Tj
4.2066 0 Td
(MDA)Tj
2.5342 0 Td
(in)Tj
1.0375 0 Td
(2005)Tj
2.1203 0 Td
(and)Tj
-34.1289 -1.2983 Td
(2008,)Tj
2.347 0 Td
(whilst)Tj
2.6022 0 Td
(financial)Tj
3.6794 0 Td
(and)Tj
1.7291 0 Td
(logistical)Tj
3.736 0 Td
(issues)Tj
2.5228 0 Td
(later)Tj
1.9899 0 Td
(prevented)Tj
4.2123 0 Td
(MDA)Tj
2.5285 0 Td
(in)Tj
1.0375 0 Td
(2012.[)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
3.3902 0 Td
(5)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
0.9184 0 Td
(7)Tj
0 g
(])Tj
1.0375 0 Td
(Additionally)Tj
-31.7308 -1.3039 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(Mandalay)Tj
4.1895 0 Td
(Region,)Tj
3.2769 0 Td
(MDA)Tj
2.5341 0 Td
(did)Tj
1.5421 0 Td
(not)Tj
1.576 0 Td
(occur)Tj
2.4718 0 Td
(in)Tj
1.0375 0 Td
(2006)Tj
2.1203 0 Td
(because)Tj
3.3222 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(reported)Tj
3.6623 0 Td
(incidence)Tj
4.0706 0 Td
(of)Tj
1.0148 0 Td
(seri-)Tj
-35.807 -1.2983 Td
(ous)Tj
1.6157 0 Td
(adverse)Tj
3.2145 0 Td
(reactions)Tj
3.855 0 Td
(during)Tj
2.9254 0 Td
(the)Tj
1.4683 0 Td
(preceding)Tj
4.1896 0 Td
(rounds,)Tj
3.2882 0 Td
(and)Tj
1.7291 0 Td
(in)Tj
1.0375 0 Td
(2010)Tj
2.1259 0 Td
(due)Tj
1.6951 0 Td
(to)Tj
1.0262 0 Td
(further)Tj
3.0274 0 Td
(DEC)Tj
2.1883 0 Td
(supply)Tj
ET
Q
q
1 j
1 J
0.0001 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.26 183.288 23.6976 re
W* n
q
183.288 0 0 23.6976 36 741.26 cm
q
/I2 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0.0001 w
7.9999 0 0 7.9999 402.973 745.795 cm
BT
/F0 1 Tf
-0.005 Tc
1 TL
0 0 Td
(Lymphatic)Tj
4.7055 0 Td
(filariasis)Tj
3.7488 0 Td
(in)Tj
0.978 0 Td
(Mandalay)Tj
4.4788 0 Td
(Region,)Tj
3.6071 0 Td
(Myanm)Tj
3.2315 0 Td
(ar)Tj
ET
Q
q
1 j
1 J
0.0001 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
163.559 34.9228 m
317.707 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
-0.005 Tc
1 TL
0 0 Td
(PLOS)Tj
2.8559 0 Td
(Neglected)Tj
4.6417 0 Td
(Tropical)Tj
3.7135 0 Td
(Disease)Tj
3.5433 0 Td
(s)Tj
0.7158 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8197 0 Td
(1/journal.pn)Tj
5.1237 0 Td
(td.00069)Tj
3.8197 0 Td
(44)Tj
0 g
2.0905 0 Td
(November)Tj
4.7623 0 Td
(12,)Tj
1.5874 0 Td
(2018)Tj
22.5781 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(17)Tj
/F8 1 Tf
-0.025 Tc
-66.402 84.0904 Td
(analysis,)Tj
3.4086 0 Td
(decision)Tj
3.2953 0 Td
(to)Tj
0.9497 0 Td
(publish,)Tj
3.1393 0 Td
(or)Tj
1.0064 0 Td
(prepara)Tj
2.8205 0 Td
(tion)Tj
1.6157 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
-17.1851 -1.3748 Td
(manuscript.)Tj
/F7 1 Tf
0 -2.126 Td
(Competing)Tj
4.3795 0 Td
(interests)Tj
3.3307 0 Td
(:)Tj
/F8 1 Tf
0.4819 0 Td
(NNA,)Tj
2.1402 0 Td
(TWN,)Tj
2.3103 0 Td
(TW,)Tj
1.722 0 Td
(and)Tj
1.5945 0 Td
(SSW)Tj
-15.9591 -1.3749 Td
(were)Tj
2.0126 0 Td
(involved)Tj
3.2882 0 Td
(in)Tj
0.8858 0 Td
(Myanmar's)Tj
4.3867 0 Td
(National)Tj
3.2386 0 Td
(LF)Tj
-13.8119 -1.3748 Td
(Elimination)Tj
4.3157 0 Td
(Program)Tj
3.4796 0 Td
(at)Tj
0.9 0 Td
(the)Tj
1.3677 0 Td
(time)Tj
1.8426 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
1.3748 0 Td
(study.)Tj
2.4874 0 Td
(MS)Tj
-16.7174 -1.3748 Td
(works)Tj
2.4803 0 Td
(as)Tj
1.063 0 Td
(a)Tj
0.6449 0 Td
(self-empl)Tj
3.437 0 Td
(oyed)Tj
2.0126 0 Td
(private)Tj
2.7142 0 Td
(general)Tj
-12.352 -1.3748 Td
(practitioner)Tj
4.4149 0 Td
(in)Tj
0.8859 0 Td
(Mandalay.)Tj
4.0252 0 Td
(He)Tj
1.226 0 Td
(volunteered)Tj
4.5567 0 Td
(his)Tj
1.3111 0 Td
(time)Tj
-16.4198 -1.3748 Td
(to)Tj
0.9496 0 Td
(assist)Tj
2.3527 0 Td
(with)Tj
1.7788 0 Td
(data)Tj
1.7929 0 Td
(collection)Tj
3.7418 0 Td
(during)Tj
2.615 0 Td
(the)Tj
1.3677 0 Td
(study.)Tj
ET
Q
endstream
endobj
51 0 obj
<>
endobj
52 0 obj
<>/XObject<>>>
endobj
53 0 obj
[56 0 R 57 0 R 58 0 R 59 0 R 60 0 R 61 0 R 62 0 R 63 0 R 64 0 R 65 0 R 66 0 R 67 0 R 68 0 R 69 0 R]
endobj
56 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref005)>>
endobj
57 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref005)>>
endobj
58 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref007)>>
endobj
59 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref009)>>
endobj
60 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref005)>>
endobj
61 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref010)>>
endobj
62 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref011)>>
endobj
63 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref012)>>
endobj
64 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref013)>>
endobj
65 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref014)>>
endobj
66 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref003)>>
endobj
67 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref015)>>
endobj
68 0 obj
<>/Border[0 0 0]/Dest(Rpntd.0006944.ref016)>>
endobj
69 0 obj
<>/Border[0 0 0]/A 70 0 R>>
endobj
70 0 obj
<>
endobj
54 0 obj
<>stream
q
Q
q
12.0189 54.5953 583.087 707.414 re
W* n
q
1 0 0 1 12.0189 54.5953 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
0.83 0.64 0.02 0 k
228.643 706.337 m
233.405 706.337 l
h
f*
394.356 641.31 m
399.118 641.31 l
h
f*
403.54 641.31 m
408.302 641.31 l
h
f*
519.647 524.296 m
524.409 524.296 l
h
f*
378.709 498.331 m
383.471 498.331 l
h
f*
535.465 472.309 m
544.989 472.309 l
h
f*
379.729 433.304 m
389.197 433.304 l
h
f*
393.676 433.304 m
403.2 433.304 l
h
f*
475.427 420.321 m
484.951 420.321 l
h
f*
489.373 420.321 m
498.898 420.321 l
h
f*
370.091 394.299 m
374.854 394.299 l
h
f*
391.805 218.608 m
401.272 218.608 l
h
f*
310.28 159.931 m
319.805 159.931 l
h
f*
0 g
1 j
1 J
0.0001 w
10 0 0 10 200.012 707.414 cm
BT
/F5 1 Tf
-0.004 Tc
1 TL
0 0 Td
(issues.[)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(])Tj
3.9004 0 Td
(As)Tj
1.2642 0 Td
(a)Tj
0.6577 0 Td
(result,)Tj
2.6702 0 Td
(six)Tj
1.3153 0 Td
(non-consecutive)Tj
6.8314 0 Td
(rounds)Tj
3.0614 0 Td
(of)Tj
1.0148 0 Td
(MDA)Tj
2.5342 0 Td
(had)Tj
1.7121 0 Td
(been)Tj
2.1203 0 Td
(completed)Tj
4.405 0 Td
(in)Tj
1.0375 0 Td
(Mandalay)Tj
-32.5245 -1.3039 Td
(Region)Tj
3.05 0 Td
(over)Tj
1.9786 0 Td
(an)Tj
1.2019 0 Td
(11-year)Tj
3.2031 0 Td
(period)Tj
2.8346 0 Td
(from)Tj
2.2054 0 Td
(2004)Tj
2.1259 0 Td
(to)Tj
1.0262 0 Td
(2014)Tj
2.1203 0 Td
(inclusive.)Tj
-18.5498 -1.2982 Td
(Although)Tj
4.0081 0 Td
(MDA)Tj
2.5342 0 Td
(has)Tj
1.542 0 Td
(been)Tj
2.1203 0 Td
(or)Tj
1.0999 0 Td
(is)Tj
0.8447 0 Td
(now)Tj
1.9615 0 Td
(being)Tj
2.4322 0 Td
(conducted)Tj
4.4276 0 Td
(in)Tj
1.0318 0 Td
(all)Tj
1.1509 0 Td
(endemic)Tj
3.651 0 Td
(IUs)Tj
1.6554 0 Td
(in)Tj
1.0375 0 Td
(Myanmar,)Tj
4.3993 0 Td
(data)Tj
-35.0926 -1.2983 Td
(on)Tj
1.2755 0 Td
(treatment)Tj
4.1329 0 Td
(coverage)Tj
3.7247 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4684 0 Td
(impact)Tj
2.982 0 Td
(of)Tj
1.0148 0 Td
(MDA)Tj
2.5342 0 Td
(on)Tj
1.2755 0 Td
(infection)Tj
3.7928 0 Td
(prevalence)Tj
4.4844 0 Td
(have)Tj
2.0579 0 Td
(been)Tj
2.126 0 Td
(lacking.)Tj
-32.5982 -1.2983 Td
(Two)Tj
2.0182 0 Td
(papers)Tj
2.846 0 Td
(\(Win)Tj
2.3414 0 Td
(et)Tj
0.9411 0 Td
(al.)Tj
1.1282 0 Td
(2018)Tj
2.1203 0 Td
(and)Tj
1.7291 0 Td
(Aye)Tj
1.7858 0 Td
(et)Tj
0.9411 0 Td
(al.)Tj
1.1282 0 Td
(2018\))Tj
2.4604 0 Td
(recently)Tj
3.4073 0 Td
(summarised)Tj
5.1363 0 Td
(NPELF)Tj
3.1464 0 Td
(data)Tj
1.9162 0 Td
(on)Tj
1.2756 0 Td
(infec-)Tj
-34.3216 -1.3039 Td
(tion)Tj
1.8425 0 Td
(prevalence)Tj
4.4843 0 Td
(and)Tj
1.7292 0 Td
(treatment)Tj
4.1385 0 Td
(coverage)Tj
3.7191 0 Td
(surveys.[)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
4.439 0 Td
(7)Tj
0 g
(])Tj
1.0375 0 Td
(They)Tj
2.2393 0 Td
(report)Tj
2.7099 0 Td
(that)Tj
1.7745 0 Td
(whilst)Tj
2.6078 0 Td
(MDA)Tj
2.5285 0 Td
(rounds)Tj
-33.2501 -1.2982 Td
(were)Tj
2.1203 0 Td
(interrupted)Tj
4.7961 0 Td
(in)Tj
1.0375 0 Td
(several)Tj
2.931 0 Td
(districts,)Tj
3.6227 0 Td
(treatment)Tj
4.1329 0 Td
(coverage)Tj
3.7247 0 Td
(has)Tj
1.542 0 Td
(been)Tj
2.1203 0 Td
(consistently)Tj
4.9606 0 Td
(high)Tj
2.0069 0 Td
(\(60.0%)Tj
2.9707 0 Td
(to)Tj
-35.9657 -1.2983 Td
(98.5%\),)Tj
3.1917 0 Td
(with)Tj
2.0013 0 Td
(significant)Tj
4.388 0 Td
(reductions)Tj
4.473 0 Td
(in)Tj
1.0375 0 Td
(prevalence)Tj
4.4844 0 Td
(in)Tj
1.0375 0 Td
(most)Tj
2.2053 0 Td
(areas)Tj
2.245 0 Td
(between)Tj
3.5263 0 Td
(2001)Tj
2.1203 0 Td
(and)Tj
1.7348 0 Td
(2016.)Tj
2.3471 0 Td
(In)Tj
-34.7922 -1.3039 Td
(Mandalay)Tj
4.1895 0 Td
(Region,)Tj
3.2769 0 Td
(mean)Tj
2.4491 0 Td
(mf)Tj
1.3266 0 Td
(prevalence)Tj
4.4844 0 Td
(in)Tj
1.0374 0 Td
(sentinel)Tj
3.3392 0 Td
(sites)Tj
1.9276 0 Td
(has)Tj
1.542 0 Td
(decreased)Tj
4.1386 0 Td
(from)Tj
2.2053 0 Td
(5.0%)Tj
2.1543 0 Td
(in)Tj
1.0318 0 Td
(2003)Tj
2.126 0 Td
(to)Tj
-35.2287 -1.2983 Td
(1.2%)Tj
2.1543 0 Td
(in)Tj
1.0318 0 Td
(2014,)Tj
2.3527 0 Td
(although)Tj
3.7531 0 Td
(some)Tj
2.33 0 Td
(districts)Tj
3.3959 0 Td
(have)Tj
2.0579 0 Td
(demonstrated)Tj
5.76 0 Td
(persistently)Tj
4.7905 0 Td
(high)Tj
2.0069 0 Td
(levels)Tj
2.3755 0 Td
(of)Tj
1.0148 0 Td
(mf)Tj
1.3322 0 Td
(preva-)Tj
-34.3556 -1.2983 Td
(lence.)Tj
2.5114 0 Td
(This)Tj
1.9843 0 Td
(NPELF)Tj
3.1521 0 Td
(data)Tj
1.9105 0 Td
(provides)Tj
3.651 0 Td
(a)Tj
0.6576 0 Td
(useful)Tj
2.5909 0 Td
(overview)Tj
3.8041 0 Td
(of)Tj
1.0148 0 Td
(Myanmar's)Tj
4.7508 0 Td
(progress)Tj
3.6 0 Td
(toward)Tj
3.0444 0 Td
(LF)Tj
1.2869 0 Td
(elimina-)Tj
-33.9588 -1.3039 Td
(tion,)Tj
2.0636 0 Td
(but)Tj
1.5533 0 Td
(the)Tj
1.4684 0 Td
(limitations)Tj
4.5354 0 Td
(of)Tj
1.0148 0 Td
(programmatic)Tj
5.947 0 Td
(data)Tj
1.9162 0 Td
(are)Tj
1.4514 0 Td
(acknowledged.)Tj
6.1511 0 Td
(Reliance)Tj
3.6056 0 Td
(on)Tj
1.2756 0 Td
(repeated)Tj
-30.9824 -1.2982 Td
(sampling)Tj
3.8777 0 Td
(of)Tj
1.0148 0 Td
(sentinel)Tj
3.3392 0 Td
(sites)Tj
1.9276 0 Td
(in)Tj
1.0374 0 Td
(historically)Tj
4.6205 0 Td
(high)Tj
2.0126 0 Td
(suspected)Tj
4.0818 0 Td
(prevalence)Tj
4.4844 0 Td
(areas)Tj
2.245 0 Td
(could)Tj
2.4548 0 Td
(have)Tj
2.058 0 Td
(over-)Tj
2.3244 0 Td
(or)Tj
-35.4782 -1.2983 Td
(under)Tj
2.6191 0 Td
(estimated)Tj
4.0706 0 Td
(current)Tj
3.1861 0 Td
(prevalence)Tj
4.4844 0 Td
(and)Tj
1.7291 0 Td
(program)Tj
3.7077 0 Td
(impact)Tj
2.982 0 Td
(given)Tj
2.3754 0 Td
(the)Tj
1.474 0 Td
(focal)Tj
2.1147 0 Td
(distribution)Tj
4.9719 0 Td
(of)Tj
1.0148 0 Td
(LF,)Tj
-34.7298 -1.3039 Td
(while)Tj
2.3697 0 Td
(programmatic)Tj
5.947 0 Td
(data)Tj
1.9106 0 Td
(is)Tj
0.8504 0 Td
(of)Tj
1.0148 0 Td
(unknown)Tj
4.0818 0 Td
(reliability)Tj
4.0025 0 Td
(for)Tj
1.3833 0 Td
(assessing)Tj
3.8041 0 Td
(MDA)Tj
2.5342 0 Td
(coverage.[)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(])Tj
5.1023 0 Td
(The)Tj
1.7801 0 Td
(pro-)Tj
-34.7808 -1.2983 Td
(gram)Tj
2.3073 0 Td
(has)Tj
1.5421 0 Td
(indicated)Tj
3.9401 0 Td
(the)Tj
1.4683 0 Td
(need)Tj
2.143 0 Td
(for)Tj
1.389 0 Td
(in-depth)Tj
3.6793 0 Td
(studies)Tj
2.9877 0 Td
(in)Tj
1.0318 0 Td
(problem)Tj
3.617 0 Td
(areas)Tj
2.2394 0 Td
(to)Tj
1.0261 0 Td
(independently)Tj
5.9754 0 Td
(verify)Tj
-33.3465 -1.2982 Td
(Myanmar's)Tj
4.7508 0 Td
(progress)Tj
3.5943 0 Td
(toward)Tj
3.0444 0 Td
(LF)Tj
1.2869 0 Td
(elimination.[)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(])Tj
-11.4802 -1.2983 Td
(Information)Tj
5.1533 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(burden)Tj
3.1238 0 Td
(of)Tj
1.0148 0 Td
(LF-related)Tj
4.3653 0 Td
(morbidity)Tj
4.235 0 Td
(in)Tj
1.0374 0 Td
(Myanmar)Tj
4.1783 0 Td
(is)Tj
0.8447 0 Td
(incomplete.)Tj
4.9209 0 Td
(A)Tj
0.9014 0 Td
(2004)Tj
-33.715 -1.3039 Td
(NPELF)Tj
3.1521 0 Td
(questionnaire)Tj
5.7032 0 Td
(provides)Tj
3.6454 0 Td
(the)Tj
1.474 0 Td
(only)Tj
1.9729 0 Td
(prevalence)Tj
4.49 0 Td
(figures)Tj
2.9197 0 Td
(from)Tj
2.2053 0 Td
(within)Tj
2.8176 0 Td
(the)Tj
1.4684 0 Td
(country.[)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(])Tj
5.21 0 Td
(The)Tj
-35.0586 -1.2983 Td
(survey)Tj
2.8119 0 Td
(assessed)Tj
3.4696 0 Td
(self-reported)Tj
5.3291 0 Td
(morbidity)Tj
4.2406 0 Td
(in)Tj
1.0375 0 Td
(280,000)Tj
3.2995 0 Td
(individuals)Tj
4.6488 0 Td
(in)Tj
1.0374 0 Td
(Sagaing)Tj
3.3052 0 Td
(Region)Tj
3.0557 0 Td
(and)Tj
1.7292 0 Td
(identi-)Tj
-33.9645 -1.2983 Td
(fied)Tj
1.7234 0 Td
(520)Tj
1.6498 0 Td
(cases)Tj
2.2223 0 Td
(of)Tj
1.0148 0 Td
(lymphoedema)Tj
5.9187 0 Td
(\(0.19%\))Tj
3.3109 0 Td
(and)Tj
1.7291 0 Td
(827)Tj
1.6497 0 Td
(cases)Tj
2.2224 0 Td
(of)Tj
1.0148 0 Td
(hydrocoele)Tj
4.6318 0 Td
(\(0.59%\).)Tj
3.5319 0 Td
(Such)Tj
2.177 0 Td
(question-)Tj
-32.7966 -1.3039 Td
(naires,)Tj
2.8516 0 Td
(however,)Tj
3.8324 0 Td
(are)Tj
1.4513 0 Td
(not)Tj
1.5761 0 Td
(sensitive)Tj
3.6226 0 Td
(or)Tj
1.0999 0 Td
(specific.[)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
4.9322 0 Td
(12)Tj
0 g
(])Tj
1.508 0 Td
(Studies)Tj
3.1011 0 Td
(of)Tj
1.0148 0 Td
(Myanmar)Tj
4.1783 0 Td
(migrants)Tj
3.787 0 Td
(living)Tj
2.4662 0 Td
(in)Tj
-35.4215 -1.2982 Td
(Thailand)Tj
3.8154 0 Td
(provide)Tj
3.2881 0 Td
(the)Tj
1.4684 0 Td
(only)Tj
1.9785 0 Td
(other)Tj
2.3471 0 Td
(indication)Tj
4.3086 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(disease)Tj
3.0217 0 Td
(prevalence.[)Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
6.2248 0 Td
(14)Tj
0 g
(])Tj
1.5137 0 Td
(A)Tj
0.9014 0 Td
(meta-analysis)Tj
-31.3509 -1.2983 Td
(of)Tj
1.0147 0 Td
(this)Tj
1.6725 0 Td
(data)Tj
1.9162 0 Td
(suggests)Tj
3.4809 0 Td
(that)Tj
1.7802 0 Td
(there)Tj
2.262 0 Td
(is)Tj
0.8504 0 Td
(likely)Tj
2.3527 0 Td
(to)Tj
1.0262 0 Td
(be)Tj
1.1508 0 Td
(a)Tj
0.652 0 Td
(more)Tj
2.3414 0 Td
(significant)Tj
4.388 0 Td
(burden)Tj
3.1294 0 Td
(of)Tj
1.0148 0 Td
(hydrocoele)Tj
4.6318 0 Td
(\(12.27%)Tj
-33.664 -1.3039 Td
(95%CI)Tj
2.931 0 Td
(6.8418.90\))Tj
4.8585 0 Td
(within)Tj
2.812 0 Td
(the)Tj
1.4683 0 Td
(population.[)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(])Tj
5.9697 0 Td
(Whilst)Tj
2.8913 0 Td
(these)Tj
2.2507 0 Td
(studies)Tj
2.9877 0 Td
(provide)Tj
3.2882 0 Td
(an)Tj
1.2019 0 Td
(indication)Tj
4.3086 0 Td
(of)Tj
-34.9679 -1.2983 Td
(prevalence)Tj
4.4843 0 Td
(within)Tj
2.812 0 Td
(the)Tj
1.474 0 Td
(country,)Tj
3.5716 0 Td
(they)Tj
1.9276 0 Td
(are)Tj
1.4456 0 Td
(not)Tj
1.5761 0 Td
(representative)Tj
5.8336 0 Td
(and)Tj
1.7348 0 Td
(do)Tj
1.2529 0 Td
(not)Tj
1.5761 0 Td
(provide)Tj
3.2882 0 Td
(any)Tj
1.6554 0 Td
(information)Tj
-32.6322 -1.2983 Td
(on)Tj
1.2755 0 Td
(lymphoedema.)Tj
6.1455 0 Td
(As)Tj
1.2642 0 Td
(a)Tj
0.652 0 Td
(result,)Tj
2.6759 0 Td
(there)Tj
2.262 0 Td
(remains)Tj
3.4469 0 Td
(no)Tj
1.2756 0 Td
(representative)Tj
5.8394 0 Td
(data)Tj
1.9105 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(prevalence)Tj
4.4901 0 Td
(of)Tj
1.0148 0 Td
(LF-)Tj
-34.9963 -1.2982 Td
(related)Tj
2.9423 0 Td
(morbidity)Tj
4.2406 0 Td
(in)Tj
1.0375 0 Td
(Myanmar.)Tj
-7.0242 -1.3039 Td
(In)Tj
1.1111 0 Td
(light)Tj
2.024 0 Td
(of)Tj
1.0148 0 Td
(this,)Tj
1.8935 0 Td
(a)Tj
0.652 0 Td
(cross-sectional)Tj
6.1057 0 Td
(survey)Tj
2.812 0 Td
(in)Tj
1.0318 0 Td
(one)Tj
1.7008 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(country's)Tj
3.9231 0 Td
(priority)Tj
3.2712 0 Td
(areas)Tj
2.245 0 Td
(was)Tj
1.6951 0 Td
(conducted.)Tj
-33.1594 -1.2983 Td
(The)Tj
1.7744 0 Td
(primary)Tj
3.4526 0 Td
(objective)Tj
3.7814 0 Td
(was)Tj
1.6951 0 Td
(to)Tj
1.0205 0 Td
(determine)Tj
4.3199 0 Td
(the)Tj
1.4627 0 Td
(prevalence)Tj
4.4844 0 Td
(of)Tj
1.0091 0 Td
(LF)Tj
1.2813 0 Td
(infection)Tj
3.787 0 Td
(and)Tj
1.7292 0 Td
(morbidity.)Tj
4.4617 0 Td
(The)Tj
1.7744 0 Td
(sec-)Tj
-36.0337 -1.2983 Td
(ondary)Tj
3.0613 0 Td
(objectives)Tj
4.1443 0 Td
(were)Tj
2.1203 0 Td
(to)Tj
1.0261 0 Td
(assess)Tj
2.5228 0 Td
(participation)Tj
5.3688 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(MDA)Tj
2.5342 0 Td
(program)Tj
3.702 0 Td
(and)Tj
1.7348 0 Td
(to)Tj
1.0205 0 Td
(explore)Tj
3.1747 0 Td
(risk)Tj
1.7178 0 Td
(factors)Tj
-34.6334 -1.3039 Td
(for)Tj
1.3832 0 Td
(infection,)Tj
4.0196 0 Td
(morbidity)Tj
4.2406 0 Td
(and)Tj
1.7291 0 Td
(MDA)Tj
2.5341 0 Td
(non-participation.)Tj
7.5515 0 Td
(Prevalence)Tj
4.524 0 Td
(data)Tj
1.9163 0 Td
(and)Tj
1.7291 0 Td
(MDA)Tj
2.5341 0 Td
(participation)Tj
-32.1616 -1.2982 Td
(are)Tj
1.4456 0 Td
(reported)Tj
3.6623 0 Td
(here,)Tj
2.1884 0 Td
(whilst)Tj
2.6078 0 Td
(analysis)Tj
3.3279 0 Td
(of)Tj
1.0148 0 Td
(risk)Tj
1.7121 0 Td
(factors)Tj
2.9027 0 Td
(for)Tj
1.3889 0 Td
(infection)Tj
3.7928 0 Td
(and)Tj
1.7291 0 Td
(MDA)Tj
2.5341 0 Td
(non-participation)Tj
7.3247 0 Td
(will)Tj
-35.6312 -1.2983 Td
(be)Tj
1.1508 0 Td
(reported)Tj
3.6567 0 Td
(separately.)Tj
ET
Q
q
1 j
1 J
0.0001 w
11.9999 0 0 11.9999 200.012 249.675 cm
BT
/F2 1 Tf
-0.0033 Tc
1 TL
0 0 Td
(Methods)Tj
ET
Q
q
1 j
1 J
0.0001 w
10 0 0 10 200.012 232.724 cm
BT
/F5 1 Tf
-0.004 Tc
1 TL
0 0 Td
(This)Tj
1.9842 0 Td
(paper)Tj
2.4831 0 Td
(is)Tj
0.8504 0 Td
(reported)Tj
3.6567 0 Td
(according)Tj
4.1896 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(Strengthening)Tj
5.8847 0 Td
(the)Tj
1.4684 0 Td
(Reporting)Tj
4.2406 0 Td
(of)Tj
1.0148 0 Td
(Observational)Tj
5.8166 0 Td
(Studies)Tj
-34.0835 -1.3039 Td
(in)Tj
1.0318 0 Td
(Epidemiology)Tj
5.7939 0 Td
(\(STROBE\))Tj
4.5071 0 Td
(recommendations.[)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(])Tj
ET
Q
q
1 j
1 J
0.0001 w
11.9999 0 0 11.9999 200.012 190.998 cm
BT
/F12 1 Tf
-0.0033 Tc
1 TL
0 0 Td
(Study)Tj
2.6173 0 Td
(area)Tj
1.9843 0 Td
(and)Tj
1.7953 0 Td
(population)Tj
ET
Q
q
1 j
1 J
0.0001 w
10 0 0 10 200.012 173.99 cm
BT
/F5 1 Tf
-0.004 Tc
1 TL
0 0 Td
(Myanmar)Tj
4.1725 0 Td
(\(formerly)Tj
4.0422 0 Td
(Burma\))Tj
3.2938 0 Td
(is)Tj
0.8504 0 Td
(a)Tj
0.652 0 Td
(lower)Tj
2.4491 0 Td
(middle-income)Tj
6.3723 0 Td
(country)Tj
3.3505 0 Td
(in)Tj
1.0375 0 Td
(Southeast)Tj
4.0762 0 Td
(Asia)Tj
1.9615 0 Td
(with)Tj
2.0013 0 Td
(a)Tj
0.6519 0 Td
(popu-)Tj
-34.9112 -1.2982 Td
(lation)Tj
2.5171 0 Td
(of)Tj
1.0148 0 Td
(52)Tj
1.1735 0 Td
(million)Tj
3.1238 0 Td
(people.[)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(])Tj
4.7111 0 Td
(The)Tj
1.7802 0 Td
(country)Tj
3.3505 0 Td
(is)Tj
0.8504 0 Td
(administratively)Tj
6.6954 0 Td
(divided)Tj
3.2145 0 Td
(into)Tj
1.8368 0 Td
(a)Tj
0.6576 0 Td
(capital)Tj
2.8403 0 Td
(territory)Tj
-33.766 -1.2983 Td
(\(Naypyitaw\),)Tj
5.4028 0 Td
(seven)Tj
2.4321 0 Td
(states)Tj
2.3981 0 Td
(and)Tj
1.7291 0 Td
(seven)Tj
2.4321 0 Td
(regions.)Tj
3.3902 0 Td
(These)Tj
2.5625 0 Td
(fifteen)Tj
2.7609 0 Td
(administrative)Tj
5.9924 0 Td
(areas)Tj
2.2394 0 Td
(are)Tj
1.4513 0 Td
(further)Tj
-32.7909 -1.3039 Td
(divided)Tj
3.2144 0 Td
(into)Tj
1.8425 0 Td
(districts,)Tj
3.617 0 Td
(townships,)Tj
4.5184 0 Td
(cities,)Tj
2.4888 0 Td
(towns,)Tj
2.8403 0 Td
(village)Tj
2.7609 0 Td
(tracts)Tj
2.4038 0 Td
(\(groups)Tj
3.3108 0 Td
(of)Tj
1.0148 0 Td
(adjacent)Tj
3.566 0 Td
(villages\))Tj
3.4582 0 Td
(and)Tj
-35.0359 -1.2983 Td
(villages.)Tj
1.1962 -1.2982 Td
(A)Tj
0.907 0 Td
(cross-sectional,)Tj
6.3269 0 Td
(population-based)Tj
7.1943 0 Td
(household)Tj
4.3767 0 Td
(survey)Tj
2.8119 0 Td
(was)Tj
1.7008 0 Td
(conducted)Tj
4.4277 0 Td
(between)Tj
3.5263 0 Td
(February)Tj
-32.4678 -1.3039 Td
(and)Tj
1.7291 0 Td
(March)Tj
2.8686 0 Td
(2015)Tj
2.1203 0 Td
(in)Tj
1.0375 0 Td
(four)Tj
1.9162 0 Td
(townships)Tj
4.2916 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(Mandalay)Tj
4.1895 0 Td
(Region)Tj
3.0558 0 Td
(in)Tj
1.0374 0 Td
(central)Tj
2.9651 0 Td
(Myanmar:)Tj
4.3993 0 Td
(Amarapura,)Tj
-32.0936 -1.2983 Td
(Patheingyi,)Tj
4.6884 0 Td
(Tada-U)Tj
3.3165 0 Td
(and)Tj
1.7292 0 Td
(Wundwin.)Tj
4.5127 0 Td
(Townships)Tj
4.6034 0 Td
(have)Tj
2.0636 0 Td
(a)Tj
0.652 0 Td
(typical)Tj
2.863 0 Td
(population)Tj
4.5921 0 Td
(of)Tj
1.0148 0 Td
(between)Tj
3.5262 0 Td
(50,000)Tj
ET
Q
q
1 j
1 J
0.0001 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.26 183.288 23.6976 re
W* n
q
183.288 0 0 23.6976 36 741.26 cm
q
/I2 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0.0001 w
7.9999 0 0 7.9999 402.973 745.795 cm
BT
/F0 1 Tf
-0.005 Tc
1 TL
0 0 Td
(Lymphatic)Tj
4.7055 0 Td
(filariasis)Tj
3.7488 0 Td
(in)Tj
0.978 0 Td
(Mandalay)Tj
4.4788 0 Td
(Region,)Tj
3.6071 0 Td
(Myanm)Tj
3.2315 0 Td
(ar)Tj
ET
Q
q
1 j
1 J
0.0001 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
163.559 34.9228 m
317.707 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
-0.005 Tc
1 TL
0 0 Td
(PLOS)Tj
2.8559 0 Td
(Neglected)Tj
4.6417 0 Td
(Tropical)Tj
3.7135 0 Td
(Disease)Tj
3.5433 0 Td
(s)Tj
0.7158 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8197 0 Td
(1/journal.pn)Tj
5.1237 0 Td
(td.00069)Tj
3.8197 0 Td
(44)Tj
0 g
2.0905 0 Td
(November)Tj
4.7623 0 Td
(12,)Tj
1.5874 0 Td
(2018)Tj
22.5781 0 Td
(3)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(17)Tj
ET
Q
endstream
endobj
71 0 obj
<>
endobj
72 0 obj
<>/XObject<>>>
endobj
75 0 obj
<>
endobj
76 0 obj
<>
endobj
79 0 obj
<>stream
MinionPro-Regular 6 )
H? HD H\ ' - 3 > H N T Z ` j q t { +2=CIU[cnz~
"(.9CIOU[elov|&-8>DPV^iuy &+/49@DGLPU[]_ahjmru|
&-4;BIPW^elsz
")07>ELSZahov} %,3:AHOV]dkry#/;JTey ! ( / 6 = D K R Y ` g n u |
$
+
2
9
@
G
N
U
\
c
j
q
x
'.5<CJQX_fmt{ #*18?FMT[bkry
"
)
0
7
>
E
J
O
W
d
q
v
$+29@GNU\cjqx '.5<CJQX_fmt{ #*18?FMT[bipw~
&-4;BIPW^elsz !(/6=DOVcpuz-B\v$<Tdy*5@Tanz!2>O_fmt{ $-6?HQZclu~ )2;DMV^gpy $-6?HQZclu~ )2;DM\enwcommaaccentAbreveAmacronAogonekAEacuteCacuteCcaronCcircumflexCdotaccentDcaronDcroatEbreveEcaronEdotaccentEmacronEngEogonekGbreveGcircumflexGcommaaccentGdotaccentHbarHcircumflexIbreveIJImacronIogonekItildeJcircumflexKcommaaccentLacuteLcaronLcommaaccentLdotNacuteNcaronNcommaaccentObreveOhungarumlautOmacronOslashacuteRacuteRcaronRcommaaccentSacuteScedillaScircumflexScommaaccentTbarTcaronTcommaaccentUbreveUhungarumlautUmacronUogonekUringUtildeWacuteWcircumflexWdieresisWgraveYcircumflexYgraveZacuteZdotaccentIdotaccentabreveamacronaogonekaeacutecacuteccaronccircumflexcdotaccentdcarondcroatebreveecaronedotaccentemacronengeogonekgbrevegcircumflexgcommaaccentgdotaccenthbarhcircumflexibreveijimacroniogonekitildejcircumflexkcommaaccentlacutelcaronlcommaaccentldotnacutencaronncommaaccentobreveohungarumlautomacronoslashacuteracutercaronrcommaaccentsacutescedillascircumflexscommaaccenttbartcarontcommaaccentubreveuhungarumlautumacronuogonekuringutildewacutewcircumflexwdieresiswgraveycircumflexygravezacutezdotaccentkgreenlandiclongsnapostrophetonosdieresistonosAlphaBetaGammaDeltaEpsilonZetaEtaThetaIotaKappaLambdaMuNuXiOmicronPiRhoSigmaTauUpsilonPhiChiPsiOmegaAlphatonosEpsilontonosEtatonosIotatonosIotadieresisOmicrontonosUpsilontonosUpsilondieresisOmegatonosuni1FBBuni1F09uni1F0Duni1F0Buni1F0Funi1FB8uni1FBAuni1FBCuni1F89uni1F8Duni1F8Buni1F8Funi1F88uni1F8Cuni1F8Auni1F8Euni1F08uni1F0Cuni1F0Auni1F0Euni1FB9uni1FC9uni1F19uni1F1Duni1F1Buni1FC8uni1F18uni1F1Cuni1F1Auni1FCBuni1F29uni1F2Duni1F2Buni1F2Funi1FCAuni1FCCuni1F99uni1F9Duni1F9Buni1F9Funi1F98uni1F9Cuni1F9Auni1F9Euni1F28uni1F2Cuni1F2Auni1F2Euni1FDBuni1F39uni1F3Duni1F3Buni1F3Funi1FD8uni1FDAuni1F38uni1F3Cuni1F3Auni1F3Euni1FD9uni1FFBuni1F69uni1F6Duni1F6Buni1F6Funi1FFAuni1FFCuni1FA9uni1FADuni1FABuni1FAFuni1FA8uni1FACuni1FAAuni1FAEuni1F68uni1F6Cuni1F6Auni1F6Euni1FF9uni1F49uni1F4Duni1F4Buni1FF8uni1F48uni1F4Cuni1F4Auni1FECuni1FEBuni1F59uni1F5Duni1F5Buni1F5Funi1FE8uni1FEAuni1FE9alphabetagammadeltaepsilonzetaetathetaiotakappalambdanuxiomicronpirhosigmatauupsilonphichipsiomegaalphatonosepsilontonosetatonosiotatonosiotadieresisomicrontonosupsilontonosupsilondieresisomegatonosiotadieresistonosupsilondieresistonosuni03C2uni0374uni0375uni037Euni03D0uni03DAuni03DEuni03E0uni03F0uni1FBDuni1FBEuni1FC1uni1FCDuni1FCEuni1FCFuni1FDDuni1FDEuni1FDFuni1FEDuni1FEEuni1FFEuni1F00uni1F01uni1F02uni1F03uni1F04uni1F05uni1F06uni1F07uni1F10uni1F11uni1F12uni1F13uni1F14uni1F15uni1F20uni1F21uni1F22uni1F23uni1F24uni1F25uni1F26uni1F27uni1F30uni1F31uni1F32uni1F33uni1F34uni1F35uni1F36uni1F37uni1F40uni1F41uni1F42uni1F43uni1F44uni1F45uni1F50uni1F51uni1F52uni1F53uni1F54uni1F55uni1F56uni1F57uni1F60uni1F61uni1F62uni1F63uni1F64uni1F65uni1F66uni1F67uni1F70uni1F71uni1F72uni1F73uni1F74uni1F75uni1F76uni1F77uni1F78uni1F79uni1F7Auni1F7Buni1F7Cuni1F7Duni1F80uni1F81uni1F82uni1F83uni1F84uni1F85uni1F86uni1F87uni1F90uni1F91uni1F92uni1F93uni1F94uni1F95uni1F96uni1F97uni1FA0uni1FA1uni1FA2uni1FA3uni1FA4uni1FA5uni1FA6uni1FA7uni1FB0uni1FB1uni1FB2uni1FB3uni1FB6uni1FB7uni1FC2uni1FC3uni1FC4uni1FC6uni1FC7uni1FD0uni1FD1uni1FD2uni1FD3uni1FD6uni1FD7uni1FE0uni1FE1uni1FE2uni1FE3uni1FE4uni1FE5uni1FE6uni1FF2uni1FF3uni1FF4uni1FF6uni1FF7uni1FB4uni1FE7uniEFD5anoteleiauni03D1uni03D5uni03D6franclirapesetaEuroafii61289estimatedpartialdiffproductsummationuni2219radicalinfinityintegralapproxequalnotequallessequalgreaterequallozengeuni02C9uniEFEDuniEFEEuniEFF1uniEFF2uniEFF3uniEFF5uniEFF7AcuteCaronDieresisDieresisAcuteDieresisGraveGraveHungarumlautMacroncyrBrevecyrFlexdblGravecyrbrevecyrflexdblgravedieresisacutedieresisgraveuniF635uniF637uniF638uniF639uniF6DCuniF63AuniF63BuniF63CuniF63DuniF63EuniF63FuniF640uniF641uniF642uniF628uniF643uniF644uniF645uniF646uniF647uniF648uniF649uniF64AuniF64BuniF64CuniF64DuniF64EuniF64FuniF650uniF651uniF652uniF653uniF654uniF655uniF656uniF657uniF658uniF659uniF65AuniF65BuniF65CuniF65DuniF65EuniF65FuniF660uniF629uniF62AuniF62BuniF62CuniF62DuniF661uniF662uniF663uniF664uniF665uniF666uniF667uniF668uniF669uniF66AuniF66BuniF66CuniF62EuniF62FuniF630uniF631uniF632uniF66DuniF66EuniF66FuniF670uniF671uniF672uniF673uniF674uniF675uniF676uniF677uniF678uniF679uniF67AuniF67BuniF67CuniF67DuniF67EuniF67FuniF680uniF681uniF682uniF683uniF684uniF685uniF686uniF687uniF688uniF689uniF68AuniF68BuniF68CuniF68DuniF68EuniF68FuniF690uniF691uniF692uniF693uniF694uniF695uniF696uniF697uniF698uniF699uniF69AuniF69BuniF69CuniF69DuniF69EuniF69FuniF6A0uniF6A1uniF6A2uniF6A3uniF6A4uniF6A5uniF6A6uniF6A7uniF6A8uniF6A9uniF6AAuniF6ABuniF6ACuniF6ADuniF6AEuniF6AFuniF6B0uniF6B1uniF6B2uniF6B3uniF6B4uniF6B5uniF6B6uniF6B7uniF6B8uniF6B9uniF6BAuniF6BBuniF6BCuniF6BDuniF633c_hc_kc_tf_bf_f_bf_f_hf_f_kf_f_tf_hf_jf_f_jf_kf_ts_puniFB06T_hlongs_blongs_hlongs_ilongs_klongs_llongs_longsuniFB05longs_longs_ilongs_longs_la.ende.endm.endn.endr.endK.altR.altk.altcaron.altcommaaccent.altpeseta.altAlphaiotasub.altAlphaiotasubasper.altAlphaiotasubasperacute.altAlphaiotasubaspergrave.altAlphaiotasubaspertilde.altAlphaiotasublenis.altAlphaiotasublenisacute.altAlphaiotasublenisgrave.altAlphaiotasublenistilde.altEtaiotasub.altEtaiotasubasper.altEtaiotasubasperacute.altEtaiotasubaspergrave.altEtaiotasubaspertilde.altEtaiotasublenis.altEtaiotasublenisacute.altEtaiotasublenisgrave.altEtaiotasublenistilde.altOmegaiotasub.altOmegaiotasubasper.altOmegaiotasubasperacute.altOmegaiotasubaspergrave.altOmegaiotasubaspertilde.altOmegaiotasublenis.altOmegaiotasublenisacute.altOmegaiotasublenisgrave.altOmegaiotasublenistilde.altEuro.fittedcent.fittedcolonmonetary.fitteddollar.fittedflorin.fittedfranc.fittedlira.fittednumbersign.fittedsterling.fittedyen.fittedEuro.oldstylecolonmonetary.oldstyleestimated.oldstyleflorin.oldstylefranc.oldstylelira.oldstylenumbersign.oldstylesterling.oldstyleyen.oldstylefranc.taboldstylelira.taboldstyleorn.001orn.002orn.003orn.004orn.005orn.006orn.007orn.008orn.009orn.010orn.011orn.012orn.013orn.014orn.015orn.016orn.017orn.018orn.019orn.020orn.021orn.022orn.023afii10023afii10031afii10022afii10049T_h.caronafii10070afii10196afii10026afii10021afii10846afii10193afii10107afii10024afii10195afii10041afii10037afii10109afii10053afii10045afii10108afii10040afii10104afii10036afii10078afii10074afii10060afii10046afii10052afii10087afii10050afii10145afii10057afii10059afii10146afii10088afii10101afii10054afii10058Rholenisafii10025afii10099afii10068afii10035afii10048afii10089afii10105afii10085afii10020afii10077afii10106afii10019afii10076afii10110afii10100afii10090afii10028afii10095afii10147afii10066afii10098afii10082afii10061afii10103afii10102afii10083afii10027afii10072afii10039afii61352afii10069afii10094afii10038afii10034afii10148afii10032afii10194afii10033afii10075afii10017afii10081afii10056afii10084afii10044afii10030afii10051afii10047afii10018afii10080afii10042afii10071afii10029afii10062afii10065afii10097T_h.commaaccentafii10096afii10079afii10091afii10093afii10064afii10043afii10092uni2215uni021Bafii10073afii10067uni00A0uni021Aafii10086afii10055uni0394uni03BCuni03A9uni00ADCopyright 2000 Adobe Systems Incorporated. All Rights Reserved. U.S. Patent Des. 337,604.Minion is either a registered trademark or a trademark of Adobe Systems Incorporated in the United States and/or other countries.Minion Pro RegularMinion Pro% i WZ5:`v22> % I
/
2
I
o
#3p~U
D
e
!o#]emE %<Jeov~EMfjtFp|,S-AZ0=DK +^&7NQy(/S_dl 5Rk$=Valsz"'-@T_gos{ ) . > N ^ d n v ~ !!!!'!3!?!H!Q!Z!]!c!i!n!s!x!!!!!!!!!!!!!"""#"'"3"?"K"W"c"k"s"{""""""""""""""c&oEr^7 JB@H *W2c~sp&m!1= 4:$kYyywRvzwrZnon?˘iNUddLoLݪ
~}}vywS6vO(Zp^TrǕ؍8x`?NYwUVYWE}zyMhummR~Kfowx}|txcBzuyBpOwTxql[LPҩy}~Bxxhzqlc#T0@9
5/j,X^M8Uruuoquvqiff{bE<H8XUo^bb_rMG'Н=[W}yQSSۚ$P|TzTyT'
ajqyzx||rrpwttozpj`lWHrʥaiqyo
|rqpxt@tpyqjalVHr]yt/m'mDx]pIsn8AgmxpQAz4wv~s}~vstzf|oęgfeoszvwzxu$wny|YgJO-ʆea]>9+ZhchAB_\?#^|m[5v-<<[FL LHHq˂~XxAo4uFabfqaf%f+rrs}ǔcqW "* ڟŇՊvx|po~}wUJN<0o-כtzr[ {"!coч~^o]/6'orsBp0ZlZqRoGt{_Fpq|iiMkTratap`DabuvCICpAϦ{~{lpˇBDDpӐ qoكtYoNU)gI_Z`yӔodžF/INlw71oC
ŸԱȗГnoՆ3$811xrdcQD:0] ;hJjp~djmplXhZfYxnmmyf^#MR:AgszvT]jjZ?_ynZQ{sNHyZdƨ]O틯֯}ޣDyZ{kvumofFMk_VYЄ#ms^@L A_!Z Z|蒯}~rqyg|usqrwgmazԬqbfZBoل5|%69o<3oZMZJuׇ3c T{ddmvrjY_VpŇkrkGpφ}8Fgsmy]pWSy/OBR7WXjfeolw}v84o~}xUGP~72pC
~㿊IK
NϪb98IPq
`y[~XsłI\FL
ދ.R۲vhl_@oۅ8(85oq͗ƫ>(3XOG7]_\i^%"Ba:Jy.}eu}|wzq]is|~ґϐuCDDEp
ؑ~P|xhcMp^},
qkuGuzwv~s}~ust}e{nęgfR5BcH
蠓`
i
`c
v
y
蠚}xsnyvrpyh&T~Y|S|Q4xrqxvrpyhrqVVrm