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One-year Mortality Outcomes From the Advancing Cryptococcal Meningitis Treatment for Africa Trial of Cryptococcal Meningitis Treatment in Malawi

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Kanyama, Cecilia, Molloy, Síle, Chan, Adrienne K, Lupiya, Duncan, Chawinga, Chimwemwe, Adams, Jack, Bright, Philip, Lalloo, David ORCID: https://orcid.org/0000-0001-7680-2200, Heyderman, Robert S, Lortholary, Olivier, Jaffar, Shabbar, Loyse, Angela, van Oosterhout, Joep J, Hosseinipour, Mina C and Harrison, Thomas (2019) 'One-year Mortality Outcomes From the Advancing Cryptococcal Meningitis Treatment for Africa Trial of Cryptococcal Meningitis Treatment in Malawi'. Clinical Infectious Diseases. (In Press)

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Abstract

In Malawi, 236 participants from the ACTA cryptococcal meningitis treatment trial were followed-up for 12 months. The trial outcomes reported at 10 weeks were sustained to 1 year. One-week amphotericinB plus flucytosine was associated with the lowest 1 year mortality (27.5% [95%CI: 16.3 to 44.1]).

Item Type: Article
Subjects: QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 252 Antifungal agents. Antifungal antibiotics
QW Microbiology and Immunology > Fungi. Pathogenic Fungi. > QW 180 Pathogenic Fungi
WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections
WL Nervous System > WL 200 Meninges. Blood-brain barrier
Faculty: Department: Clinical Sciences & International Health > International Public Health Department
Digital Object Identifer (DOI): https://doi.org/10.1093/cid/ciz454
Depositing User: Stacy Murtagh
Date Deposited: 05 Jun 2019 10:19
Last Modified: 05 Aug 2019 09:19
URI: https://archive.lstmed.ac.uk/id/eprint/10954

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